ArticlePloS one2016
Baseline Predictors of Mortality among Predominantly Rural-Dwelling End-Stage Renal Disease Patients on Chronic Dialysis Therapies in Limpopo, South Africa.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Peritoneal dialysis versus haemodialysis for people commencing dialysis.The Cochrane database of systematic reviews · 2024Pooled it
- Relationship between sex and cardiovascular mortality in chronic kidney disease: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Spatial distribution of mortality: evidence from DIMAMO HDSS, Limpopo Province, South Africa.BMC public health · 2025Article
- Adverse clinical outcomes and associated factors among older adults undergoing hemodialysis in Brazil: A single-center experience.PloS one · 2025Article
- Factors affecting access to dialysis for patients with end-stage kidney disease in Sub-Saharan Africa: A scoping review.Nursing open · 2023Article
- Epidemiology of peritoneal dialysis outcomes.Nature reviews. Nephrology · 2022Review
- Global eHealth capacity: secondary analysis of WHO data on eHealth and implications for kidney care delivery in low-resource settings.BMJ open · 2022Article
- International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Africa.Kidney international supplements · 2021Review
- Cardiovascular Risk Factor Profiles and Disease in Black Compared to Other Africans with Chronic Kidney Disease.International journal of nephrology · 2021Article
- Survival of South African patients on renal replacement therapy.Clinical kidney journal · 2020Article
- Atherosclerotic vascular disease is more prevalent among black ESKD patients on long-term CAPD in South Africa.BMC nephrology · 2019Article
- Health economic evaluation of peritoneal dialysis based on cost-effectiveness in Japan: a preliminary study.ClinicoEconomics and outcomes research : CEOR · 2019Article
- Article
- Non-medical facilitators and barriers towards accessing haemodialysis services: an exploration of ethical challenges.BMC nephrology · 2018Article
- Development and validation of risk prediction models for cardiovascular mortality in Chinese people initialising peritoneal dialysis: a cohort study.Scientific reports · 2018Article
- Continuous ambulatory peritoneal dialysis: perspectives on patient selection in low- to middle-income countries.International journal of nephrology and renovascular disease · 2017Review
- Public-private partnership in hemodialysis in Nigeria: A comparative analysis of renal centers across three Northwestern states.Annals of African medicineArticle
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDialysis therapy for end-stage renal disease (ESRD) continues to be the readily available renal replacement option in developing countries. While the impact of rural/remote dwelling on mortality among dialysis patients in developed countries is known, it remains to be defined in sub-Saharan Africa.
methodsA single-center database of end-stage renal disease patients on chronic dialysis therapies treated between 2007 and 2014 at the Polokwane Kidney and Dialysis Centre (PKDC) of the Pietersburg Provincial Hospital, Limpopo South Africa, was retrospectively reviewed. All-cause, cardiovascular, and infection-related mortalities were assessed and associated baseline predictors determined.
resultsOf the 340 patients reviewed, 52.1% were male, 92.9% were black Africans, 1.8% were positive for the human immunodeficiency virus (HIV), and 87.5% were rural dwellers. The average distance travelled to the dialysis centre was 112.3 ± 73.4 Km while 67.6% of patients lived in formal housing. Estimated glomerular filtration rate (eGFR) at dialysis initiation was 7.1 ± 3.7 mls/min while hemodialysis (HD) was the predominant modality offered (57.1%). Ninety-two (92) deaths were recorded over the duration of follow-up with the majority (34.8%) of deaths arising from infection-related causes. Continuous ambulatory peritoneal dialysis (CAPD) was a significant predictor of all-cause mortality (HR: 1.62, CI: 1.07-2.46) and infection-related mortality (HR: 2.27, CI: 1.13-4.60). On multivariable cox regression, CAPD remained a significant predictor of all-cause mortality (HR: 2.00, CI: 1.29-3.10) while the risk of death among CAPD patients was also significantly modified by diabetes mellitus (DM) status (HR: 4.99, CI: 2.13-11.71).
conclusionCAPD among predominantly rural dwelling patients in the Limpopo province of South Africa is associated with an increased risk of death from all-causes and infection-related causes.
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