ArticleAdvances in skin & wound care2016
Keloid Management: A Retrospective Case Review on a New Approach Using Surgical Excision, Platelet-Rich Plasma, and In-office Superficial Photon X-ray Radiation Therapy.
Article in Advances in skin & wound care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- LangerinClinical, cosmetic and investigational dermatology · 2025Review
- Pharmacotherapy for Keloids and Hypertrophic Scars.International journal of molecular sciences · 2024Review
- Mapping variation of extracellular matrix in human keloid scar by label-free multiphoton imaging and machine learning.Journal of biomedical optics · 2023Article
- An updated review of the immunological mechanisms of keloid scars.Frontiers in immunology · 2023Review
- The outcome of postoperative radiation therapy following plastic surgical resection of recurrent ear keloid: a single institution experience.Journal of the Egyptian National Cancer Institute · 2022Article
- Platelet-Rich Plasma: A Comprehensive Review of Emerging Applications in Medical and Aesthetic Dermatology.The Journal of clinical and aesthetic dermatology · 2021Review
- Review
- A Review of Current Keloid Management: Mainstay Monotherapies and Emerging Approaches.Dermatology and therapy · 2020Review
- A Retrospective Registry Study Evaluating the Long-Term Efficacy and Safety of Superficial Radiation Therapy Following Excision of Keloid Scars.The Journal of clinical and aesthetic dermatology · 2020Review
- Monoclonal Antibodies Addressed to Factors of Signalization in Keloid Scars: Opportunities and Areas of Action.Cureus · 2020Review
- Assessing keloid recurrence following surgical excision and radiation.Burns & trauma · 2020Review
- Combining micro-plasma radio-frequency with hypofractionated electron-beam radiation as a novel treatment of keloids: A case series.Medicine · 2019Article
- Review
- Surgical Excision of Keloids Followed by In-office Superficial Radiation Therapy: Prospective Study Examining Clinical Outcomes.Plastic and reconstructive surgery. Global open · 2019Article
- Article
- Helical rim advancement - A technique to avoid keloid recurrence.JPRAS open · 2019Article
- Excessive applicator radiation leakage for a common therapeutic kilovoltage system.The British journal of radiology · 2019Article
- A Novel Radiotherapy Approach for Keloids with Intrabeam.BioMed research international · 2019Article
- Understanding Keloid Pathobiology From a Quasi-Neoplastic Perspective: Less of a Scar and More of a Chronic Inflammatory Disease With Cancer-Like Tendencies.Frontiers in immunology · 2019Review
- Keloid risk in patients with atopic dermatitis: a nationwide retrospective cohort study in Taiwan.BMJ open · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this retrospective study was to evaluate the efficacy of the authors' combination therapy protocol for keloid treatment.
designRetrospective.
settingPlastic surgery office-based outpatient setting in New York City. PATIENTS: Forty patients with 44 keloid scars requiring surgical excision.
interventionsKeloid scars were treated using surgical excision, platelet-rich plasma, and postoperative in-office superficial photon X-ray radiation therapy. Intralesional triamcinolone injections were administered once to 4 patients with poor results on scar scale assessment. Patient follow-up visits ranged from 3 to 11 months to assess for evidence of recurrence and adverse effects. MAIN OUTCOME MEASURE(S): For the purpose of this study, recurrence was defined as any sign of extraordinary erythema, induration, and hypertrophy beyond the site of excision. MAIN
resultsIn the 16 keloids treated with 2 fractions, there was no evidence of recurrence. One of 25 keloids treated with 3 fractions demonstrated evidence of recurrence. One of 3 keloids treated with a single fraction displayed signs of recurrence. Postirradiation hyperpigmentation was noted in all patients.
conclusionsSurgical excision combined with platelet-rich plasma and postoperative in-office superficial radiation therapy achieved a 95.5% nonrecurrence rate at 1- to 3-month follow-up. This protocol appears to be a safe and viable option in the management of keloids and merits further randomized controlled study of its comparative efficacy.
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Registered trials
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