Evidence map›Paper›PMID 27300352›Full record

SynthesisEuropean journal of epidemiology2017

Association between periodontitis and ischemic stroke: a systematic review and meta-analysis.

Yago Leira, Juan Seoane, Miguel Blanco, Manuel Rodríguez-Yáñez, Bahi Takkouche, Juan Blanco, José Castillo

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  9. Analysis the Link between Periodontal Diseases and Alzheimer's Disease: A Systematic Review.International journal of environmental research and public health · 2021
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  14. Oral Health and Brain Injury: Causal or Casual Relation?Cerebrovascular diseases extra · 2018
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yago LeiraDepartment of Periodontology, Faculty of Medicine, School of Dentistry, University of Santiago de Compostela, Rúa Entrerríos, S/N, 15782, Santiago de Compostela, A Coruña, Spain. yagoleira@gmail.com.
Juan SeoaneDepartment of Periodontology, Faculty of Medicine, School of Dentistry, University of Santiago de Compostela, Rúa Entrerríos, S/N, 15782, Santiago de Compostela, A Coruña, Spain.
Miguel BlancoClinical Neurosciences Research Laboratory, Department of Neurology, Neurovascular Area, Health Research Institute of Santiago de Compostela (IDIS), Hospital Clínico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain.
Manuel Rodríguez-YáñezClinical Neurosciences Research Laboratory, Department of Neurology, Neurovascular Area, Health Research Institute of Santiago de Compostela (IDIS), Hospital Clínico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain.
Bahi TakkoucheDepartment of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain.
Juan BlancoDepartment of Periodontology, Faculty of Medicine, School of Dentistry, University of Santiago de Compostela, Rúa Entrerríos, S/N, 15782, Santiago de Compostela, A Coruña, Spain.
José CastilloClinical Neurosciences Research Laboratory, Department of Neurology, Neurovascular Area, Health Research Institute of Santiago de Compostela (IDIS), Hospital Clínico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several observational studies have suggested an association between periodontitis and cerebral ischemia. This meta-analysis aimed to investigate whether this link exists, and if so, the degree to which it is significant. The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guideline for systematic review was used. The search strategy included using electronic databases and hand searching works published up to March 2015. MEDLINE via PubMed, EMBASE, Proceedings Web of Science and Current Contents Connect were searched by two independent reviewers. Case-control, cross-sectional or cohort studies including patients with measures of periodontitis and ischemic stroke were eligible to be included in the analysis. Quality assessments of selected studies were performed. From a total of 414 titles and abstracts, 57 potentially relevant full text papers were identified. After inclusion criteria were applied, 8 studies were included in the present systematic review (5 case-control and 3 cohort studies). Although it was not the intention, cross-sectional studies were excluded due to eligibility criteria were not accomplished. Therefore, meta-analyses were conducted with data retrieved from the 8 studies included. These meta-analyses showed statistically significant association between periodontitis and ischemic stroke in both cohort pooled relative risks at 2.52 (1.77-3.58), and case-control studies pooled relative risks at 3.04 (1.10-8.43). In conclusion, the present meta-analysis demonstrated an association between periodontitis and ischemic stroke. However, well-designed prospective studies should be carried out to provide robust evidence of the link between both diseases. In regards to ischemic stroke subtypes, further case-control studies should be carried out to investigate whether there is any association between the different subtypes of cerebral infarcts and periodontitis.

Indexed as

PeriodontitisStrokeHumansRisk FactorsIschemic strokeMeta-analysisPeriodontitisRisk factors

Identifiers

PMID27300352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.