ArticleeLife2016
Interactions between respiratory oscillators in adult rats.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 71 citations in OpenAlex.
- Plasticity induced loss of apnea alarm through repeated apneas: A proposed mechanism for respiratory sudden death.Epilepsy & behavior : E&B · 2025Review
- Respiratory and Metabolic Effects of Active Expiration in Freely Behaving Rats.Acta physiologica (Oxford, England) · 2025Article
- Neuroanatomical and neurochemical organization of brainstem and forebrain circuits involved in breathing regulation.Journal of neurophysiology · 2025Review
- Neural bases for the genesis and COFrontiers in neuroscience · 2023Article
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- Analyzing the brainstem circuits for respiratory chemosensitivity in freely moving mice.eLife · 2022Article
- A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing.Neuron · 2022Article
- Transcription factors regulating the specification of brainstem respiratory neurons.Frontiers in molecular neuroscience · 2022Review
- Central respiratory chemoreception.Handbook of clinical neurology · 2022Review
- Respiratory disturbances and high risk of sudden death in the neonatal connexin-36 knockout mouse.Physiological reports · 2021Article
- Role of DSCAM in the Development of Neural Control of Movement and Locomotion.International journal of molecular sciences · 2021Review
- Neuronal mechanisms underlying opioid-induced respiratory depression: our current understanding.Journal of neurophysiology · 2021Review
- Maternal Methadone Destabilizes Neonatal Breathing and Desensitizes Neonates to Opioid-Induced Respiratory Frequency Depression.Frontiers in physiology · 2021Article
- Differential Contribution of the Retrotrapezoid Nucleus and C1 Neurons to Active Expiration and Arousal in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Differential modulation of active expiration during hypercapnia by the medullary raphe in unanesthetized rats.Pflugers Archiv : European journal of physiology · 2020Article
- Multi-Level Regulation of Opioid-Induced Respiratory Depression.Physiology (Bethesda, Md.) · 2020Review
- Inhibitory control of active expiration by the Bötzinger complex in rats.The Journal of physiology · 2020Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Breathing in mammals is hypothesized to result from the interaction of two distinct oscillators: the preBötzinger Complex (preBötC) driving inspiration and the lateral parafacial region (pFL) driving active expiration. To understand the interactions between these oscillators, we independently altered their excitability in spontaneously breathing vagotomized urethane-anesthetized adult rats. Hyperpolarizing preBötC neurons decreased inspiratory activity and initiated active expiration, ultimately progressing to apnea, i.e., cessation of both inspiration and active expiration. Depolarizing pFL neurons produced active expiration at rest, but not when inspiratory activity was suppressed by hyperpolarizing preBötC neurons. We conclude that in anesthetized adult rats active expiration is driven by the pFL but requires an additional form of network excitation, i.e., ongoing rhythmic preBötC activity sufficient to drive inspiratory motor output or increased chemosensory drive. The organization of this coupled oscillator system, which is essential for life, may have implications for other neural networks that contain multiple rhythm/pattern generators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.