Evidence map›Paper›PMID 27300264›Full record

ArticleTranslational psychiatry2016

Obesity and age-related alterations in the gene expression of zinc-transporter proteins in the human brain.

R H Olesen, T M Hyde, J E Kleinman, K Smidt, J Rungby, A Larsen

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. An emerging role for synaptic ZnPharmacology & therapeutics · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Therapeutic potential of zincFrontiers in pharmacology · 2025
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Total plasma magnesium, zinc, copper and selenium concentrations in obese patients before and after bariatric surgery.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

R H OlesenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
T M HydeLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
J E KleinmanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
K SmidtDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
J RungbyDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
A LarsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Aarhus University · DKJohns Hopkins Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of Alzheimer's disease (AD) is increasing. Major risk factors for AD are advancing age and diabetes. Lately, obesity has been associated with an increased risk of dementia. Obese and diabetic individuals are prone to decreased circulating levels of zinc, reducing the amount of zinc available for crucial intracellular processes. In the brain, zinc co-localizes with glutamate in synaptic vesicles, and modulates NMDA receptor activity. Intracellular zinc is involved in apoptosis and fluctuations in cytoplasmic Zn(2+) affect modulation of intracellular signaling. The ZNT and ZIP proteins participate in intracellular zinc homeostasis. Altered expression of zinc-regulatory proteins has been described in AD patients. Using microarray data from human frontal cortex (BrainCloud), this study investigates expression of the SCLA30A (ZNT) and SCLA39A (ZIP) families of genes in a Caucasian and African-American sample of 145 neurologically and psychiatrically normal individuals. Expression of ZNT3 and ZNT4 were significantly reduced with increasing age, whereas expression of ZIP1, ZIP9 and ZIP13 were significantly increased. Increasing body mass index (BMI) correlated with a significant reduction in ZNT1 expression similar to what is seen in the early stages of AD. Increasing BMI also correlated with reduced expression of ZNT6. In conclusion, we found that the expression of genes that regulate intracellular zinc homeostasis in the human frontal cortex is altered with increasing age and affected by increasing BMI. With the increasing rates of obesity throughout the world, these findings warrant continuous scrutiny of the long-term consequences of obesity on brain function and the development of neurodegenerative diseases.

Indexed as

AdultAgedAged, 80 and overAge FactorsAlzheimer DiseaseBlack or African AmericanBody Mass IndexCarrier ProteinsCation Transport ProteinsDatabases, GeneticDNA-Binding ProteinsFemaleFrontal LobeGene ExpressionHomeostasisHumansCarrier ProteinsCation Transport ProteinsDNA-Binding ProteinsIntracellular Signaling Peptides and ProteinsRNA, MessengerSLC30A3 protein, humanSLC30A4 protein, humanSLC39A13 protein, humanSLC39A1 protein, humanSlc39a9 protein, humanTranscription Factor MTF-1Transcription FactorsZinczinc-binding protein

Identifiers

PMID27300264
PMCPMC4931611
OpenAlexW2423681796

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.