Evidence map›Paper›PMID 27300199›Full record

ArticleEuropean radiology2017

Differentiation of prostate cancer lesions with high and with low Gleason score by diffusion-weighted MRI.

Sebastiano Barbieri, Michael Brönnimann, Silvan Boxler, Peter Vermathen, Harriet C Thoeny

Abstract read
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In one paragraph

Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. The predictive value of multiparametric MRI combined with [European journal of nuclear medicine and molecular imaging · 2025
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  7. State-of-the-art Prostate Imaging.Sisli Etfal Hastanesi tip bulteni · 2023
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  12. Efficacy ofQuantitative imaging in medicine and surgery · 2022
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  14. Article
  15. Clinical application and progress of quantitative functional magnetic resonance imaging in prostate cancer.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
  16. Article
  17. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sebastiano BarbieriInstitute of Diagnostic, Pediatric, and Interventional Radiology, Inselspital University Hospital, Inselspital, Freiburgstrasse 10, CH-3010, Bern, Switzerland.
Michael BrönnimannInstitute of Diagnostic, Pediatric, and Interventional Radiology, Inselspital University Hospital, Inselspital, Freiburgstrasse 10, CH-3010, Bern, Switzerland.
Silvan BoxlerDepartment of Urology, Inselspital, Inselspital University Hospital, Bern, Switzerland.
Peter VermathenInstitute of Diagnostic, Pediatric, and Interventional Radiology, Inselspital University Hospital, Inselspital, Freiburgstrasse 10, CH-3010, Bern, Switzerland.
Harriet C ThoenyInstitute of Diagnostic, Pediatric, and Interventional Radiology, Inselspital University Hospital, Inselspital, Freiburgstrasse 10, CH-3010, Bern, Switzerland. Harriet.Thoeny@insel.ch.
University Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo differentiate prostate cancer lesions with high and with low Gleason score by diffusion-weighted-MRI (DW-MRI).

methodsThis prospective study was approved by the responsible ethics committee. DW-MRI of 84 consenting prostate and/or bladder cancer patients scheduled for radical prostatectomy were acquired and used to compute apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM: the pure diffusion coefficient D

resultsMean ADC and D

conclusionsClassification by IVIM parameters was not superior to classification by ADC. DW-MRI parameters correlated with Gleason score but did not provide sufficient information to classify individual patients. KEY POINTS: • Mean ADC and diffusion coefficient differ between high- and low-grade prostatic lesions. • Accuracy of trivariate logistic regression is not superior to using ADC alone. • DW-MRI is not a valid substitute for biopsies in clinical routine yet.

Indexed as

AdultAgedAged, 80 and overDiagnosis, DifferentialDiffusion Magnetic Resonance ImagingHumansImage Interpretation, Computer-AssistedMaleMiddle AgedNeoplasm GradingProspective StudiesProstateProstatectomyProstatic NeoplasmsADCDiffusion-weighted MRIIVIMLogistic regressionProstate cancer

Identifiers

PMID27300199
OpenAlexW2427210130

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.