Evidence map›Paper›PMID 27300162›Full record

ArticlePloS one2016

A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans.

David Carr, Leticia Sanchez-Alvarez, Janice H Imai, Cristina Slatculescu, Nathaniel Noblett, Lei Mao, Lorena Beese, Antonio Colavita

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

David CarrNeuroscience Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Leticia Sanchez-AlvarezNeuroscience Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Janice H ImaiNeuroscience Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Cristina SlatculescuNeuroscience Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Nathaniel NoblettNeuroscience Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Lei MaoDepartment of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America.
Lorena BeeseDepartment of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America.
Antonio ColavitaNeuroscience Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Duke Medical Center · USOttawa Hospital · CAUniversity of Ottawa · CAOttawa Hospital Research InstituteuOttawa Brain and Mind Research Institute

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Genetic pathways that regulate nascent neurite formation play a critical role in neuronal morphogenesis. The core planar cell polarity components VANG-1/Van Gogh and PRKL-1/Prickle are involved in blocking inappropriate neurite formation in a subset of motor neurons in C. elegans. A genetic screen for mutants that display supernumerary neurites was performed to identify additional factors involved in this process. This screen identified mutations in fntb-1, the β subunit of farnesyltransferase. We show that fntb-1 is expressed in neurons and acts cell-autonomously to regulate neurite formation. Prickle proteins are known to be post-translationally modified by farnesylation at their C-terminal CAAX motifs. We show that PRKL-1 can be recruited to the plasma membrane in both a CAAX-dependent and CAAX-independent manner but that PRKL-1 can only inhibit neurite formation in a CAAX-dependent manner.

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsFarnesyltranstransferaseIntracellular Signaling Peptides and ProteinsModels, MolecularMutationNeuritesPrenylationProtein Processing, Post-TranslationalProtein SubunitsCaenorhabditis elegans ProteinsFarnesyltranstransferaseIntracellular Signaling Peptides and ProteinsPRKL-1 protein, C elegansProtein Subunits

Identifiers

PMID27300162
PMCPMC4907426
OpenAlexW2427184700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.