Evidence map›Paper›PMID 27300033›Full record

ArticleJournal of endocrinological investigation2016

Plasma total oxidant and antioxidant status after oral glucose tolerance and mixed meal tests in patients with polycystic ovary syndrome.

Zehra Kucukaydın, Cevdet Duran, Mustafa Basaran, Fatos Camlica, Sami Said Erdem, Ahmet Basaran, Orkide Kutlu, Ferda Sevimli Burnik, Halis Elmas, Mustafa Sait Gonen

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zehra KucukaydınDivision of Obstetrics and Gynecology, Konya Training and Research Hospital, Konya, Turkey.
Cevdet DuranDivision of Endocrinology and Internal Medicine, Division of Endocrinology and Metabolism, Konya Training and Research Hospital, Meram Yeniyol, 42100, Meram, Konya, Turkey. drcduran@gmail.com.
Mustafa BasaranDivision of Obstetrics and Gynecology, Konya Training and Research Hospital, Konya, Turkey.
Fatos CamlicaErmenek State Hospital, Ermenek, Karaman, Turkey.
Sami Said ErdemDivision of Biochemistry, Konya Training and Research Hospital, Konya, Turkey.
Ahmet BasaranDivision of Obstetrics and Gynecology, Konya Training and Research Hospital, Konya, Turkey.
Orkide KutluDivision of Internal Medicine, Okmeydani Training and Research Hospital, Istanbul, Turkey.
Ferda Sevimli BurnikDivision of Endocrinology and Internal Medicine, Konya Training and Research Hospital, Konya, Turkey.
Halis ElmasDivision of Internal Medicine, Konya Training and Research Hospital, Konya, Turkey.
Mustafa Sait GonenDivision of Endocrinology and Internal Medicine, Medical Faculty, Istanbul Bilim University, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInsulin resistance (IR) and increased oxidative stress (OS) are the characteristics of polycystic ovary syndrome (PCOS). In this study, we aimed to evaluate the effects of oral glucose tolerance (OGTT) and mixed meal tests (MMT) on plasma total oxidant (TOS) and total antioxidant status (TAS) in patients with PCOS and the relationship between these parameters and IR, calculated via homeostasis of model assessment-IR (HOMA-IR) and Matsuda's insulin sensitivity index (ISI) derived from OGTT and MMT.

methodsTwenty-two patients with PCOS, and age- and body mass index (BMI)-matched 20 women as controls were enrolled into the study. Five-hour OGTT and MMT were performed on different days, and before and after these tests, plasma TOS and TAS levels were investigated. IR was calculated with HOMA-IR and Matsuda's ISI.

resultsHOMA-IR levels were higher in patients with PCOS, compared to controls, while Matsuda's ISI derived from OGTT and MMT was higher in controls. Plasma TOS levels before OGTT and MMT were higher in patients with PCOS than controls, while TAS levels were similar. After OGTT, plasma TOS levels became decreased at 5th hour, when compared to baseline values in PCOS group. Likewise, the same decrement was found in controls, but the decrement was not significant. After OGTT and MMT at 5th hour, no changes were observed in TAS levels, compared to baseline.

conclusionMatsuda's ISIs derived from OGTT and MMT can be used instead of each other, and interestingly, we found a decrease in TOS levels after OGTT in patients with PCOS.

Indexed as

Oxidative StressAdolescentAdultAnthropometryAntioxidantsBiomarkersCase-Control StudiesFemaleGlucoseGlucose IntoleranceGlucose Tolerance TestHumansInsulin ResistanceOxidantsPolycystic Ovary SyndromeYoung AdultAntioxidantsBiomarkersGlucoseOxidantsInsulin resistanceMixed meal testOral glucose tolerance testPolycystic ovary syndromeTotal antioxidant statusTotal oxidant status

Identifiers

PMID27300033

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.