ArticleAlzheimer disease and associated disorders
Screening Utility of the King-Devick Test in Mild Cognitive Impairment and Alzheimer Disease Dementia.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brief cognitive screening instruments for early detection of Alzheimer's disease: a systematic review.Alzheimer's research & therapy · 2019Pooled it
- Trial
- Mobile Universal Lexicon Evaluation System (MULES) test: A new measure of rapid picture naming for concussion.Journal of the neurological sciences · 2017Trial
- Tablet-Based Assessment of Picture Naming in Prodromal Alzheimer's Disease: An Accessible and Effective Tool for Distinguishing Mild Cognitive Impairment from Normal Aging.Dementia and geriatric cognitive disorders · 2026Article
- Performance of teenaged action video game players on the Developmental Eye Movement and King-Devick tests.PloS one · 2025Article
- A single Center study of the Symbol Digit Modalities test as a screening tool for cognitive impairment in Parkinson's disease.Clinical parkinsonism & related disorders · 2025Article
- Research Progress of Eye Movement Analyses and its Detection Algorithms in Alzheimer's Disease.Current Alzheimer research · 2024Review
- Associations between white matter integrity of the cingulum bundle, surrounding gray matter regions, and cognition across the dementia continuum.The Journal of comparative neurology · 2023Article
- Early detection of cognitive decline in Alzheimer's disease using eye tracking.Frontiers in aging neuroscience · 2023Article
- Eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review.Frontiers in psychology · 2023Review
- Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Developmental Eye Movement (DEM) and King-Devick (K-D) Performance in Multiple Sclerosis.Brain sciences · 2022Article
- Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2022Article
- Inhibitory Control of Saccadic Eye Movements and Cognitive Impairment in Mild Cognitive Impairment.Frontiers in aging neuroscience · 2022Article
- Differential Impact on Isolated REM Sleep without Atonia by Varying Antidepressant Therapies.Journal of affective disorders reports · 2020Article
- Socioeconomic status and race as social determinants of health to be considered in clinical use of pre-season vestibular and oculomotor tests for concussion.Journal of clinical and translational research · 2020Article
- Hippocampal Resting-State Functional Connectivity Patterns are More Closely Associated with Severity of Subjective Memory Decline than Whole Hippocampal and Subfield Volumes.Cerebral cortex communications · 2020Article
- Afferent and Efferent Visual Markers of Alzheimer's Disease: A Review and Update in Early Stage Disease.Frontiers in aging neuroscience · 2020Article
- Contrast Acuity and the King-Devick Test in Huntington's Disease.Neuro-ophthalmology (Aeolus Press) · 2020Article
- Differentiating Between Healthy Control Participants and Those with Mild Cognitive Impairment Using Volumetric MRI Data.Journal of the International Neuropsychological Society : JINS · 2019Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
The King-Devick (K-D) test is a 1 to 2 minute, rapid number naming test, often used to assist with detection of concussion, but also has clinical utility in other neurological conditions (eg, Parkinson disease). The K-D involves saccadic eye and other eye movements, and abnormalities thereof may be an early indicator of Alzheimer disease (AD)-associated cognitive impairment. No study has tested the utility of the K-D in AD and we sought to do so. The sample included 206 [135 controls, 39 mild cognitive impairment (MCI), and 32 AD dementia] consecutive subjects from the Boston University Alzheimer's Disease Center registry undergoing their initial annual evaluation between March 2013 and July 2015. The K-D was administered during this period. Areas under the receiver operating characteristic curves generated from logistic regression models revealed the K-D test distinguished controls from subjects with cognitive impairment (MCI and AD dementia) [area under the curve (AUC)=0.72], MCI (AUC=0.71) and AD dementia (AUC=0.74). K-D time scores between 48 and 52 seconds were associated with high sensitivity (>90.0%) and negative predictive values (>85.0%) for each diagnostic group. The K-D correlated strongly with validated attention, processing speed, and visual scanning tests. The K-D test may be a rapid and simple effective screening tool to detect cognitive impairment associated with AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.