SynthesisEuropean child & adolescent psychiatry2017
P300 amplitude and latency in autism spectrum disorder: a meta-analysis.
Synthesis in European child & adolescent psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Cortical Auditory Processing of Simple Stimuli Is Altered in Autism: A Meta-analysis of Auditory Evoked Responses.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Pooled it
- Temporal Changes in Effect Sizes of Studies Comparing Individuals With and Without Autism: A Meta-analysis.JAMA psychiatry · 2019Pooled it
- Meta-analysis and systematic review of the literature characterizing auditory mismatch negativity in individuals with autism.Neuroscience and biobehavioral reviews · 2018Pooled it
- Task force Guideline of Brazilian Society of Otology ‒ hearing loss in children - Part I ‒ Evaluation.Brazilian journal of otorhinolaryngologyGuideline
- Empathy and event related potentials before and after EEG based neurofeedback training in autistic adolescents.Scientific reports · 2025Trial
- Attention to Social and Non-Social Stimuli in a Continuous Performance Test in Autistic and Typically Developed Participants: An ERP Study.Journal of autism and developmental disorders · 2026Article
- Locus coeruleus modulation of neurophysiological sensory selectivity differs in autism and other mental health conditions.Translational psychiatry · 2026Article
- A symphony of functioning: exploring the interplay of cognition, movement, and visual demands in adolescents on the autism spectrum using mobile brain-body imaging (MoBI).Journal of neurodevelopmental disorders · 2026Article
- Recurrent neural network models reveal unified mechanisms generating event-related potentials from MMN to P300.bioRxiv : the preprint server for biology · 2025Article
- A symphony of functioning: Assessing the interplay of cognition, movement, and visual processing in adolescents on the autism spectrum using mobile brain-body imaging (MoBI).Research square · 2025Article
- Article
- Specific dynamic facial expression evoked responses show distinct perceptual and attentional features in autism connected to social communication and GABA phenotypes.Scientific reports · 2025Article
- The discriminate value of event-related potentials in executive function of ADHD and comorbidity of ADHD and ASD.Scientific reports · 2025Article
- Where do neurodevelopmental conditions fit in transdiagnostic psychiatric frameworks? Incorporating a new neurodevelopmental spectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Detecting Central Auditory Processing Disorders in Awake Mice.Brain sciences · 2023Article
- Value of P300 amplitude in the diagnosis of untreated first-episode schizophrenia and psychosis risk syndrome in children and adolescents.BMC psychiatry · 2023Article
- Reliability and stability of oddball P300 amplitude in older adults: The role of stimulus sequence effects.Brain and cognition · 2023Article
- High-Definition Transcranial Direct Current Stimulation Improves Decision-Making Ability: A Study Based on EEG.Brain sciences · 2023Article
- Mismatch Negativity in Children and Adolescents with Autism Spectrum Disorder.International archives of otorhinolaryngology · 2023Article
- Machine Learning Enabled P300 Classifier for Autism Spectrum Disorder Using Adaptive Signal Decomposition.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorder (ASD) is an early onset neurodevelopmental disorder. Evidence suggests that ASD patients have abnormalities in information processing. Event-related potential (ERP) technique can directly record brain neural activity in real time. P300 is a positive ERP component which can measure the neuroelectrophysiological characteristics of human beings and has the potential to discover the pathological mechanism of ASD. However, P300 studies on ASD patients are incongruent and the disparities may be caused by several factors. By searching PubMed, Embase and Cochrane Library databases, a meta-analysis of P300 component difference between ASD group and typically developed (TD) control group was conducted. Results of amplitude and latency of P3b and P3a from included studies were synthesized. Random effect model was chosen and standardized mean difference (SMD) was calculated. Subgroup analysis was used to identify the source of heterogeneity and to test the effect of different experiment factors. A total of 407 ASD patients and 457 TD controls from 32 studies were included in this analysis. Reduced amplitude of P3b was found in ASD group (SMD = -0.505, 95 % CI -0.873, -0.138) compared with TD group, but no difference of P3b latency, P3a amplitude, or P3a latency was found between groups. Subgroup analysis showed that oddball paradigm elicited attenuated P3b amplitude in Pz electrode among ASD subjects. This meta-analysis suggests ASD patients have abnormalities in P300 component, which may represent for deficits in cognition, attention orientation and working memory processing, particularly in the decision-making processing condition.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.