ReviewCurrent psychiatry reports2016
Sleep Spindle Deficit in Schizophrenia: Contextualization of Recent Findings.
Review in Current psychiatry reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Sleep Spindle Abnormalities as Neurophysiological Biomarkers of Schizophrenia Spectrum Disorders: From Cellular Mechanisms and Neural Circuits to Clinical Implications.Biological psychiatry · 2025Review
- OpenSpindleNet: An open-source deep learning network for reliable sleep spindle detection in scalp and intracranial EEG.Computers in biology and medicine · 2025Article
- Competitive roles of slow/delta oscillation-nesting-mediated sleep disruption under acute methamphetamine exposure in monkeys.Journal of Zhejiang University. Science. B · 2025Article
- CB-1 receptor agonist drastically changes oscillatory activity, defining active sleep.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sleep Power Topography in Children with Attention Deficit Hyperactivity Disorder (ADHD).Children (Basel, Switzerland) · 2022Article
- Sleep disturbances in schizophrenia: what we know, what still needs to be done.Current opinion in psychology · 2020Review
- Neuromodulation of sleep rhythms in schizophrenia: Towards the rational design of non-invasive brain stimulation.Schizophrenia research · 2020Review
- Autistic Traits Are Associated With Decreased Activity of Fast Sleep Spindles During Adolescence.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders.Translational psychiatry · 2018Article
- Sleep endophenotypes of schizophrenia: slow waves and sleep spindles in unaffected first-degree relatives.NPJ schizophrenia · 2018Article
- Schizophrenia and sleep disorders: links, risks, and management challenges.Nature and science of sleep · 2017Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep spindles are wax and waning brain oscillations at a frequency range of 11-16 Hz, lasting 0.5-2 s, that define non-rapid eye movement sleep stage 2. Over the past few years, several independent studies pointed to a decrease of sleep spindles in schizophrenia. The aim of this review is to contextualize these findings within the growing literature on these oscillations across other neuro-psychiatric disorders. Indeed, spindles reflect the coordinated activity of thalamocortical networks, and their abnormality can be observed in a variety of conditions that disrupt local or global thalamocortical connectivity. Although the broad methodological variability across studies limits the possibility of drawing firm conclusions, impaired spindling activity has been observed in several neurodevelopmental and neurodegenerative disorders. Despite such lack of specificity, schizophrenia remains the only condition with a typical late adolescence to young adulthood onset in which impaired spindling has been consistently reported. Further research is necessary to clearly define the pathogenetic mechanisms that lead to this deficit and the validity of its widespread use as a clinical biomarker.
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Registered trials
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