ArticleFood and environmental virology2016
Reduction of Enteric Viruses by Blueberry Juice and Blueberry Proanthocyanidins.
Article in Food and environmental virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Deep Eutectic Solvent-Assisted Ultrasonic Extraction of Anthocyanins from Blueberry Pomace: Optimization, Mechanistic Insights and In Vitro Antioxidant Activity.Molecules (Basel, Switzerland) · 2026Article
- Polyphenol-Based Functional Materials: Structural Insights, Composite Strategies, and Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Anti-DENV-2 Activity of Ethanolic Extracts fromPlants (Basel, Switzerland) · 2024Article
- The effects of blueberry (Food science & nutrition · 2024Article
- Human Norovirus Surrogate Is Highly Stable in Berry Smoothies and under In Vitro Simulated Digestion.Foods (Basel, Switzerland) · 2024Article
- Antiviral Effects of Quillaja saponaria Extracts Against Human Noroviral Surrogates.Food and environmental virology · 2023Article
- Proanthocyanidin Structure-Activity Relationship Analysis by Path Analysis Model.International journal of molecular sciences · 2023Article
- The Extraction and High Antiproliferative Effect of Anthocyanin from Gardenblue Blueberry.Molecules (Basel, Switzerland) · 2023Article
- Comparison of the virucidal efficacy of essential oils (cinnamon, clove, and thyme) against hepatitis A virus in suspension and on food-contact surfaces.Current research in food science · 2023Article
- Tackling the Future Pandemics: Broad-Spectrum Antiviral Agents (BSAAs) Based on A-Type Proanthocyanidins.Molecules (Basel, Switzerland) · 2022Review
- Role of bioactive compounds in the treatment of hepatitis: A review.Frontiers in pharmacology · 2022Review
- Preparation of blueberry anthocyanin liposomes and changes of vesicle properties, physicochemical properties, in vitro release, and antioxidant activity before and after chitosan modification.Food science & nutrition · 2022Article
- The New Face of Berries: A Review of Their Antiviral Proprieties.Foods (Basel, Switzerland) · 2021Review
- Natural Products and Their Potential Anti-HAV Activity.Pathogens (Basel, Switzerland) · 2021Review
- Antiviral Potential of Plants against Noroviruses.Molecules (Basel, Switzerland) · 2021Review
- Regulation of Enteric Infection and Immunity by Dietary Proanthocyanidins.Frontiers in immunology · 2021Review
- Development of antiviral and bacteriostatic chitosan-based food packaging material with grape seed extract for murine norovirus,Food science & nutrition · 2020Article
- Inhibitory Effects ofViruses · 2020Article
- Antiviral Activity of Essential Oils Against Hepatitis A Virus in Soft Fruits.Food and environmental virology · 2019Article
- Monomeric catechin and dimeric procyanidin B2 against human norovirus surrogates and their physicochemical interactions.Food microbiology · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blueberry and blueberry extracts are known for their health benefits and antimicrobial properties. Natural therapeutic or preventive options to decrease the incidences of foodborne viral illnesses are becoming popular and being researched. This study aimed to determine the antiviral effects of blueberry juice (BJ) and blueberry proanthocyanidins (BB-PAC, B-type PAC structurally different from A-type PAC found in cranberries) against the infectivity of hepatitis A virus (HAV) and human norovirus surrogates (feline calicivirus (FCV-F9) and murine norovirus (MNV-1)) at 37 °C over 24 h using standard plaque assays. Viruses at ~5 log PFU/ml were mixed with equal volumes of BJ (pH 2.8), neutralized BJ (pH 7.0), BB-PAC (1, 2, 4, and 10 mg/ml), malic acid (pH 3.0), or phosphate-buffered saline (pH 7.2) and incubated over 24 h at 37 °C. Each experiment was carried out in duplicate and replicated thrice. FCV-F9 titers were found to be reduced to undetectable levels with 1 and 2 mg/ml BB-PAC after 5 min, with 0.5 mg/ml BB-PAC after 1-h, and with BJ after 3-h. MNV-1 titers were reduced to undetectable levels after 3 h with 1, 2, and 5 mg/ml BB-PAC and after 6 h with BJ. HAV titers were reduced to undetectable levels after 30 min with 2 and 5 mg/ml BB-PAC, after 3 h with 1 mg/ml BB-PAC, and by ~2 log PFU/ml with BJ after 24-h. BB-PAC shows preventive potential against infection by the tested enteric viruses in a dose- and time-dependent manner, although further in vitro studies in model food systems and in vivo studies using animal models are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.