Evidence map›Paper›PMID 27299572›Full record

ArticleLasers in medical science2016

Nonlinear optical microscopy for label-free detection of gastrointestinal neuroendocrine tumors.

Lianhuang Li, Liwei Jiang, Zhifen Chen, Deyong Kang, Zhenrong Yang, Xing Liu, Weizhong Jiang, Shuangmu Zhuo, Guoxian Guan, Yongjian Zhou and 1 more

Abstract read
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In one paragraph

Article in Lasers in medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Lianhuang LiInstitute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, 350007, China.
Liwei JiangInstitute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, 350007, China.
Zhifen ChenDepartment of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Deyong KangDepartment of Pathology, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Zhenrong YangDepartment of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Xing LiuDepartment of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Weizhong JiangDepartment of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Shuangmu ZhuoInstitute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, 350007, China.
Guoxian GuanDepartment of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Yongjian ZhouDepartment of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, China. zyjbju@sina.com.
Jianxin ChenInstitute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, 350007, China. chenjianxin@fjnu.edu.cn.
Fujian Medical University · CNFujian Normal University · CNUnion Hospital · CNChung Yuan Christian University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroendocrine tumors (NETs), which are rare and slow-growing neoplasms, pose a diagnostic challenge as they are clinically silent at the time of presentation. Here, gastrointestinal neuroendocrine tumors were researched by nonlinear microscopy, and results demonstrate that this technique has the capability to identify neuroendocrine tumors in the absence of labels and can, in particular, detect rare neuroendocrine tumor cells, vascular invasion, desmoplastic reaction, and fibroelastosis induced by neuroendocrine tumors. These conclusions highlight the possibility of nonlinear optical microscopy as a diagnostic tool for label-freely differentiating neuroendocrine tumors by these histopathologic features.

Indexed as

Gastrointestinal NeoplasmsHumansMicroscopyNeuroendocrine TumorsGastrointestinal neuroendocrine tumorsNonlinear optical microscopySecond harmonic generation (SHG)Two-photon excited fluorescence (TPEF)

Identifiers

PMID27299572
OpenAlexW2432340477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.