ReviewCurrent osteoporosis reports2016
Crosstalk Between Muscle and Bone Via the Muscle-Myokine Irisin.
Review in Current osteoporosis reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 73 citations in OpenAlex.
- From Molecular Pathways to Artificial Intelligence: Advancing the Understanding and Management of Osteosarcopenia.International journal of molecular sciences · 2026Review
- Genomic structural equation modeling decodes skeletal aging: novel loci discovery and multisystem genetic crosstalk.Journal of translational medicine · 2025Article
- Aging: A struggle for beneficial to overcome negative factors made by muscle and bone.Mechanisms of ageing and development · 2025Review
- Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets.Canadian journal of physiology and pharmacology · 2024Review
- Bone-organ axes: bidirectional crosstalk.Military Medical Research · 2024Review
- Research trends and hotspot evolution of exercise-regulated myokines: a bibliometric analysis from 2003 to 2023.Frontiers in physiology · 2024Review
- Physical exercise for a healthy pregnancy: the role of placentokines and exerkines.The journal of physiological sciences : JPS · 2023Review
- Microgravity and Musculoskeletal Health: What Strategies Should Be Used for a Great Challenge?Life (Basel, Switzerland) · 2023Review
- Roles of miR-196a and miR-196b in Zebrafish Motor Function.Biomolecules · 2023Article
- The roles of sclerostin and irisin on bone and muscle of orchiectomized rats.BMC musculoskeletal disorders · 2022Article
- Irisin and Bone in Sickness and in Health: A Narrative Review of the Literature.Journal of clinical medicine · 2022Review
- Physical Activity and Post-Transcriptional Regulation of Aging Decay: Modulation of Pathways in Postmenopausal Osteoporosis.Medicina (Kaunas, Lithuania) · 2022Review
- Renal failure suppresses muscle irisin expression, and irisin blunts cortical bone loss in mice.Journal of cachexia, sarcopenia and muscle · 2022Article
- Role of irisin in physiology and pathology.Frontiers in endocrinology · 2022Review
- Irisin at the crossroads of inter-organ communications: Challenge and implications.Frontiers in endocrinology · 2022Review
- Serum Levels of Irisin Predict Cumulative Clinical Outcomes in Heart Failure Patients With Type 2 Diabetes Mellitus.Frontiers in physiology · 2022Article
- Exercise Therapy for People With Sarcopenic Obesity: Myokines and Adipokines as Effective Actors.Frontiers in endocrinology · 2022Review
- Irisin Enhances Angiogenesis of Mesenchymal Stem Cells to Promote Cardiac Function in Myocardial Infarction via PI3k/Akt Activation.International journal of stem cells · 2021Article
- Effects of competitive physical activity on serum irisin levels and bone turnover markers.Journal of endocrinological investigation · 2021Article
- Role of Physical Activity in Bone-Muscle Crosstalk: Biological Aspects and Clinical Implications.Journal of functional morphology and kinesiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several lines of evidence have recently established that skeletal muscle is an endocrine organ producing and releasing myokines acting in a paracrine or endocrine fashion. Among these, the newly identified myokine Irisin, produced by skeletal muscle after physical exercise, was originally described as molecule able to promote energy expenditure in white adipose tissue. Recently, it has been shown that the myokine Irisin affects skeletal metabolism in vivo. Thus, mice treated with a micro-dose of r-Irisin displayed improved cortical bone mass, geometry and strength, resembling the effect of physical activity in developing an efficient load-bearing skeleton. Further studies highlighted the autocrine effect of Irisin on skeletal muscle, and research performed in humans has definitively established that Irisin is a circulating hormone-like myokine, increased by physical activity. Albeit there are still few, since Irisin has been very recently discovered, herein are summarized the most relevant research findings published on this topic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.