ArticleNetherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation2016
Safety and efficacy of a device to narrow the coronary sinus for the treatment of refractory angina: A single-centre real-world experience.
Article in Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
REDUCER-I: An Observational Study of the Neovasc Reducer™ System
The Influence of Coronary Sinus Reducer Implantation on Exertional Capacity, Extent of Myocardial Ischemia and hrECG Markers of Arrhythmogenicity in Patients With Refractory Angina Pectoris
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- The efficacy and safety of coronary sinus reducer in refractory angina: a systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Case Report: Transient Complete Atrioventricular Block During Coronary Sinus Reducer Implantation: An Unexpected Complication.Reports (MDPI) · 2026Article
- Use of a Novel, Self-Expanding Coronary Sinus Reducer to Treat Symptomatic Epicardial and Microvascular Ischemic Heart Disease: Preclinical and First-in-Human Experience.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- Device-Based Therapies for Refractory Angina.Journal of clinical medicine · 2025Review
- Coronary Sinus Reducer Therapy for Refractory Angina and its Role in Modern Interventional Practice: A Contemporary Review.Interventional cardiology (London, England) · 2024Review
- Refractory angina pectoris: a 20-year (2003-2022) bibliometric analysis.Frontiers in cardiovascular medicine · 2023Article
- The Coronary Sinus Reducer; 5-year Dutch experience.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2021Article
- Coronary Sinus Reducer for the Treatment of Chronic Refractory Angina: Will This Challenge the Treatment of Coronary Chronic Total Occlusions?Current cardiology reports · 2021Review
- Son of a Lesser God: The Case of Cell Therapy for Refractory Angina.Frontiers in cardiovascular medicine · 2021Review
- Non-pharmacological Treatment of Refractory Angina and Microvascular Angina.Biomedicines · 2020Review
- The Coronary Sinus Reducer - Clinical Evidence and New Perspectives On An Emerging Tool in the Treatment of Refractory Angina.Heart international · 2020Review
- Linking cell function with perfusion: insights from the transcatheter delivery of bone marrow-derived CD133Stem cell research & therapy · 2018Article
- New Advances in the Management of Refractory Angina Pectoris.European cardiology · 2018Review
- Sneaking in through the back door.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2017Article
- Reply to comments from Paz and Shinfeld to article entitled 'Safety and efficacy of a device to narrow the coronary sinus for the treatment of refractory angina: a single-centre real-world experience'.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2016Article
- The coronary sinus reducer for the treatment of refractory angina.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2016Article
- Management of Refractory Angina Pectoris.European cardiology · 2016Review
- Percutaneous Device to Narrow the Coronary Sinus: Shifting Paradigm in the Treatment of Refractory Angina? A Review of the Literature.Frontiers in cardiovascular medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe coronary sinus Reducer is a recently introduced device to treat patients with severe angina symptoms refractory to optimal medical therapy and not amenable for conventional revascularisation. We aimed to assess the safety and efficacy of the Reducer in a real-world cohort of patients with refractory angina.
methodsThis is a single-centre retrospective registry. Patients with severe angina symptoms, objective evidence of myocardial ischaemia using any adequate non-invasive modality and without options for conventional revascularisation were regarded eligible for Reducer implantation.
resultsTwenty-three patients (74 % male, mean age 70 ± 8 years, 91.3 % previous bypass surgery, 82.6 % previous percutaneous intervention, 47.8 % previous myocardial infarction, 52.2 % diabetes mellitus) underwent Reducer implantation. The safety endpoint (successful implantation of the first device without device-related adverse events) was met in all patients. After a median follow-up of 9 (8-14) months the efficacy (any reduction in Canadian Cardiovascular Society (CCS) class and revascularisation-free survival) was reached in 17 patients (74 %): 8 patients (34.8 %) improved by 1 CCS class, 7 (30.4 %) by 2 CCS classes and 2 (8.7 %) by 3 CCS classes. One patient died 4 months after implantation because of progressive heart failure (not associated with Reducer implantation).
conclusionIn this single-centre real-world experience, Reducer implantation was safe and demonstrated excellent clinical efficacy in the treatment of refractory angina at mid-term follow-up.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.