Evidence map›Paper›PMID 27298831›Full record

ReviewJournal of immunology research2016

Regulatory T Cells: Molecular Actions on Effector Cells in Immune Regulation.

Asiel Arce-Sillas, Diana Denisse Álvarez-Luquín, Beatriz Tamaya-Domínguez, Sandra Gomez-Fuentes, Abel Trejo-García, Marlene Melo-Salas, Graciela Cárdenas, Juan Rodríguez-Ramírez, Laura Adalid-Peralta

Abstract readReview
In one paragraph

Review in Journal of immunology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  12. Development of a preclinical model of ICU-associated sleep fragmentation and effects on pneumonia recovery in mice.American journal of physiology. Lung cellular and molecular physiology · 2025
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Asiel Arce-SillasInstituto Nacional de Neurología y Neurocirugía, 14269 México, DF, Mexico.
Diana Denisse Álvarez-LuquínInstituto Nacional de Neurología y Neurocirugía, 14269 México, DF, Mexico.
Beatriz Tamaya-DomínguezInstituto Nacional de Neurología y Neurocirugía, 14269 México, DF, Mexico.
Sandra Gomez-FuentesInstituto Nacional de Neurología y Neurocirugía, 14269 México, DF, Mexico.
Abel Trejo-GarcíaInstituto Nacional de Neurología y Neurocirugía, 14269 México, DF, Mexico.
Marlene Melo-SalasInstituto Nacional de Neurología y Neurocirugía, 14269 México, DF, Mexico.
Graciela CárdenasInstituto Nacional de Neurología y Neurocirugía, 14269 México, DF, Mexico.
Juan Rodríguez-RamírezInstituto Nacional de Neurología y Neurocirugía, 14269 México, DF, Mexico.
Laura Adalid-PeraltaInstituto Nacional de Neurología y Neurocirugía, 14269 México, DF, Mexico; Unidad Periférica del Instituto de Investigaciones Biomédicas en el Instituto Nacional de Neurología y Neurocirugía, 14269 México, DF, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T regulatory cells play a key role in the control of the immune response, both in health and during illness. While the mechanisms through which T regulatory cells exert their function have been extensively described, their molecular effects on effector cells have received little attention. Thus, this revision is aimed at summarizing our current knowledge on those regulation mechanisms on the target cells from a molecular perspective.

Indexed as

ImmunomodulationAnimalsCell CommunicationCytokinesCytotoxicity, ImmunologicDendritic CellsGranzymesHumansImmune SystemImmunityLymphocyte ActivationPerforinSignal TransductionT-Lymphocytes, RegulatoryCytokinesGranzymesPerforin

Identifiers

PMID27298831
PMCPMC4889823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.