Evidence map›Paper›PMID 27298828›Full record

ReviewBioMed research international2016

The Discovery of Novel Genomic, Transcriptomic, and Proteomic Biomarkers in Cardiovascular and Peripheral Vascular Disease: The State of the Art.

Stefano de Franciscis, Laurent Metzinger, Raffaele Serra

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05134597 (Th17- Gene Expression Profile in Patients With Chronic Venous Leg Insufficiency and Ulcers), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05134597 unknown statusnot on this mapstarted 2021, after this paper: background citation

Th17- Gene Expression Profile in Patients With Chronic Venous Leg Insufficiency and Ulcers: Genetical and Clinical Outcomes

TypeobservationalSponsorUniversity of CatanzaroRan2021 to 2022Enrolled30ConditionsGenetic Predisposition to Disease, Inflammation, Venous Leg UlcerArmsGenetic assessment
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Molecular Determinants of Chronic Venous Disease: A Comprehensive Review.International journal of molecular sciences · 2023
    Review
  5. Review
  6. MicroRNA and Hemostasis Profile of Carotid Atherosclerosis.International journal of molecular sciences · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Association of theInternational journal of clinical and experimental pathology · 2018
    Article
  18. Association of theInternational journal of clinical and experimental pathology · 2017
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Stefano de FranciscisInteruniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy; Department of Medical and Surgical Sciences, University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Laurent MetzingerC.U.R.S, Laboratoire INSERM U1088, Chemin du Thil, Université de Picardie Jules Verne, 80025 Amiens Cedex 1, France.
Raffaele SerraInteruniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy; Department of Medical and Surgical Sciences, University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Magna Graecia University · ITInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease (CD) and peripheral vascular disease (PVD) are leading causes of mortality and morbidity in western countries and also responsible of a huge burden in terms of disability, functional decline, and healthcare costs. Biomarkers are measurable biological elements that reflect particular physiological or pathological states or predisposition towards diseases and they are currently widely studied in medicine and especially in CD. In this context, biomarkers can also be used to assess the severity or the evolution of several diseases, as well as the effectiveness of particular therapies. Genomics, transcriptomics, and proteomics have opened new windows on disease phenomena and may permit in the next future an effective development of novel diagnostic and prognostic medicine in order to better prevent or treat CD. This review will consider the current evidence of novel biomarkers with clear implications in the improvement of risk assessment, prevention strategies, and medical decision making in the field of CD.

Indexed as

Cardiovascular DiseasesGene Expression ProfilingGenomicsPeripheral Vascular DiseasesBiomarkersGenetic MarkersHumansBiomarkersGenetic Markers

Identifiers

PMID27298828
PMCPMC4889798
OpenAlexW2401046283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.