ArticleJournal of exercise nutrition & biochemistry2016
Hepatoprotective effects of hoveniae semen cum fructus extracts in ethanol intoxicated mice.
Article in Journal of exercise nutrition & biochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Synergistic Protective Effect of Fermented Schizandrae Fructus Pomace and Hoveniae Semen cum Fructus Extracts Mixture in the Ethanol-Induced Hepatotoxicity.Antioxidants (Basel, Switzerland) · 2023Article
- A Mixture of Fermented Schizandrae Fructus Pomace and Hoveniae Semen cum Fructus Extracts Synergistically Protects against Oxidative Stress-Mediated Liver Injury.Antioxidants (Basel, Switzerland) · 2023Article
- Hepatoprotective effect of botanical drug formula on high-fat diet-induced non-alcoholic fatty liver disease by inhibiting lipogenesis and promoting anti-oxidation.Frontiers in pharmacology · 2022Article
- Review
- Molecular Mechanisms That Link Oxidative Stress, Inflammation, and Fibrosis in the Liver.Antioxidants (Basel, Switzerland) · 2020Review
- Protective effects ofFood science and biotechnology · 2018Article
- Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease.Cellular and molecular life sciences : CMLS · 2018Review
- Piperine enhances carbohydrate/fat metabolism in skeletal muscle during acute exercise in mice.Nutrition & metabolism · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe objective of this study was to evaluate the hepatoprotective effects of Hoveniae Semen Cum Fructus extract in ethanol induced hepatic damages.
methodsHepatic damages were induced by oral administration of ethanol and then Hoveniae Semen Cum Fructus extract was administered.
resultsFollowing Hoveniae Semen Cum Fructus extract administration, body and liver weights were increased, while aspartate aminotransferase, alanine aminotransferase, albumin, γ-glutamyl transferase, and triglyceride levels in the serum, triglyceride contents, tumor necrosis factor -α level, cytochrome (CY) P450 2E1 activity in the liver and mRNA expression of hepatic lipogenic genes, and Nitrotyrosine and 4-HNE-immunolabelled hepatocytes were decreased. However, mRNA expression of genes involved in fatty acid oxidation was increased. Also, as a protective mechanism for hepatic antioxidant defense systems, decreased liver MDA contents, increased glutathione contents, increased dismutase and catalase activities were observed when compared to the ethanol control.
conclusionHoveniae Semen Cum Fructus extract favorably protected against liver damages, mediated by its potent anti-inflammatory and anti-steatosis properties through the augmentation of the hepatic antioxidant defense system by NF-E2-related factor-2 activation, and down-regulation of the mRNA expression of hepatic lipogenic genes or up-regulation of the mRNA expression of genes involved in fatty acid oxidation.
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Registered trials
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