Evidence map›Paper›PMID 27298812›Full record

ArticleJournal of exercise nutrition & biochemistry2016

Age Impaired endothelium-dependent vasodilation is improved by resveratrol in rat mesenteric arteries.

Semil S Gocmez, Philip J Scarpace, Melissa A Whidden, Benedek Erdos, Nataliya Kirichenko, Yasemin Sakarya, Tijen Utkan, Nihal Tumer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of exercise nutrition & biochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Sex Differences in the Relation Between Frailty and Endothelial Dysfunction in Old Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Semil S GocmezDepartment of Pharmacology, Kocaeli University, Kocaeli, 41380 Turkey.
Philip J ScarpaceDepartment of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610 United States.
Melissa A WhiddenDepartment of Kinesiology, West Chester University, West Chester, PA 19383 United States.
Benedek ErdosDepartment of Pharmacology, University of Vermont, Burlington, VT 05405 United States.
Nataliya KirichenkoGeriatric Research, Education, and Clinical Center, North Florida/ South Georgia Veterans Health System, Gainesville, FL 32608United States; Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610United States.
Yasemin SakaryaGeriatric Research, Education, and Clinical Center, North Florida/ South Georgia Veterans Health System, Gainesville, FL 32608United States; Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610United States.
Tijen UtkanDepartment of Pharmacology, Kocaeli University, Kocaeli, 41380 Turkey.
Nihal TumerGeriatric Research, Education, and Clinical Center, North Florida/ South Georgia Veterans Health System, Gainesville, FL 32608United States; Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610United States.
Kocaeli Üniversitesi · TRNorth Florida/South Georgia Veterans Health System · USGeriatric Research Education and Clinical Center · USUniversity of Florida · USUniversity of Vermont · USWest Chester University · US

Funding

TRAINING IN THE NEUROBIOLOGY OF AGINGT32AG000196 · NIA · UNIVERSITY OF FLORIDA · PI SCARPACE, PHILIP J · 1989 to 2011
$2.0M
NIA NIH HHS T32 AG000196
6 · The paper itself

Abstract

purposeTo determine whether resveratrol improves the adverse effects age on vascular function in mesenteric arteries (MAs), and diminishes the hyperactivity in adrenal gland with age.

methodsMale F344 x Brown Norway rats were assigned to 6-month control (YC), 6-month resveratrol (YR), 24-month control (OC) and 24-month resveratrol (OR). Resveratrol (15 mg/kg) was provided to resveratrol groups in drinking water for 14 days.

resultsConcentration response curves to phenylephrine (PE, 10(-9)-10(-5)M), acetylcholine (Ach, 10(-9)-10(-5)M) and resveratrol (10(-8)-10(-4)M) were evaluated in pressurized isolated MAs. The Ach concentration-response curve was right shifted with maximal response diminished in OC compared with YC rats. These effects were reversed by resveratrol treatment. The resveratrol-mediated relaxant responses were unchanged with age or resveratrol suggesting an endothelium-independent mechanism. Resveratrol tended to increase endothelial nitric oxide synthase; caused no effect on copper-zinc superoxide dismutase; and normalized the age-related elevatation in DβH and NPY levels in adrenal medulla, two indicators of sympathetic activity.

conclusionThese data indicate that resveratrol reverses age-related dysfunction in endothelium-dependent vasodilation in MAs and partially reverses hyperactivity of adrenomedullary function with age. This treatment may have a therapeuticpotential in the treatment of cardiovascular diseases or hypertension in the elderly.

Indexed as

adrenalAgingcatecholaminesmesenteric arteryresveratrol

Identifiers

PMID27298812
PMCPMC4899900
OpenAlexW2341536835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.