ArticleNeuroImage. Clinical2016
Increased frontal functional networks in adult survivors of childhood brain tumors.
Article in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Executive function after childhood cancer: Insights from network neuroscience.Neuro-oncology advances · 2026Review
- Cognitive and cortical network alterations in pediatric temporal lobe space-occupying lesions: an fMRI study.Frontiers in human neuroscience · 2024Article
- Cognitive deficits and altered functional brain network organization in pediatric brain tumor patients.Brain imaging and behavior · 2023Article
- Graph analysis of resting state functional brain networks and associations with cognitive outcomes in survivors of pediatric brain tumor.Neuroimage. Reports · 2023Article
- Pilot Study of Associations Among Functional Connectivity and Neurocognition in Survivors of Pediatric Brain Tumor and Healthy Peers.Journal of child neurology · 2022Article
- Functional network alterations in young brain tumor patients with radiotherapy-induced memory impairments and vascular injury.Frontiers in neurology · 2022Article
- Altered stability of brain functional architecture after sleep deprivation: A resting-state functional magnetic resonance imaging study.Frontiers in neuroscience · 2022Article
- Cerebellar-Subcortical-Cortical Systems as Modulators of Cognitive Functions.Neuropsychology review · 2021Review
- Brain Imaging in Pediatric Cancer Survivors: Correlates of Cognitive Impairment.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Review
- Impact of non-CNS childhood cancer on resting-state connectivity and its association with cognition.Brain and behavior · 2021Article
- Brain connectivity and cognitive functioning in individuals six months after multiorgan failure.NeuroImage. Clinical · 2020Article
- Future considerations for pediatric cancer survivorship: Translational perspectives from developmental neuroscience.Developmental cognitive neuroscience · 2019Review
- Neurodevelopmental consequences of pediatric cancer and its treatment: applying an early adversity framework to understanding cognitive, behavioral, and emotional outcomes.Neuropsychology review · 2018Review
- [Research on the rest functional magnetic resonance imaging before and after smoking cessation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2018Article
- Neuronal correlates of cognitive function in patients with childhood cerebellar tumor lesions.PloS one · 2017Article
- Article
- Disrupted functional connectivity affects resting state based language lateralization.NeuroImage. Clinical · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Childhood brain tumors and associated treatment have been shown to affect brain development and cognitive outcomes. Understanding the functional connectivity of brain many years after diagnosis and treatment may inform the development of interventions to improve the long-term outcomes of adult survivors of childhood brain tumors. This work investigated the frontal region functional connectivity of 16 adult survivors of childhood cerebellar tumors after an average of 14.9 years from diagnosis and 16 demographically-matched controls using resting state functional MRI (rs-fMRI). Independent component analysis (ICA) was applied to identify the resting state activity from rs-fMRI data and to select the specific regions associated with executive functions, followed by the secondary analysis of the functional networks connecting these regions. It was found that survivors exhibited differences in the functional connectivity in executive control network (ECN), default mode network (DMN) and salience network (SN) compared to demographically-matched controls. More specifically, the number of functional connectivity observed in the survivors is higher than that in the controls, and with increased strength, or stronger correlation coefficient between paired seeds, in survivors compared to the controls. Observed hyperconnectivity in the selected frontal functional network thus is consistent with findings in patients with other neurological injuries and diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.