Evidence map›Paper›PMID 27298759›Full record

ArticleLeukemia research reports2016

Genomic imbalances in peripheral blood confirm the diagnosis of myelodysplastic syndrome in a patient presenting with non-immune hemolytic anemia.

Mohammad Faizan Zahid, Nadia Khan, Jianming Pei, Joseph R Testa, Essel Dulaimi

Open access · goldAbstract read
In one paragraph

Article in Leukemia research reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Mohammad Faizan ZahidMedical College, Aga Khan University, Karachi, Pakistan; Department of Medical Oncology, Fox Chase Cancer Center - Temple University Health System, Philadelphia, PA 19111, USA.
Nadia KhanDepartment of Medical Oncology, Fox Chase Cancer Center - Temple University Health System, Philadelphia, PA 19111, USA.
Jianming PeiCancer Biology Program, Fox Chase Cancer Center - Temple University Health System, Philadelphia, PA 19111, USA.
Joseph R TestaCancer Biology Program, Fox Chase Cancer Center - Temple University Health System, Philadelphia, PA 19111, USA.
Essel DulaimiDepartment of Pathology, Fox Chase Cancer Center - Temple University Health System, 333 Cottman Avenue, Philadelphia, PA, USA.
Temple University Health System · USFox Chase Cancer Center · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
NCI NIH HHS P30 CA006927
6 · The paper itself

Abstract

Myelodysplastic syndrome (MDS) is a clonal stem-cell disorder characterized by dyshematopoiesis. We report a patient who presented with cytopenias and microangiopathic hemolytic anemia. Chromosome microarray analysis (CMA), using single nucleotide polymorphism arrays, on peripheral blood revealed genomic imbalances indicative of MDS, which was confirmed by bone marrow examination. This report highlights the importance of suspecting MDS in patients with cytopenias and microangiopathic hemolytic anemia. CMA of peripheral blood may assist in the preliminary diagnosis of MDS, representing a comparatively less invasive diagnostic procedure and may aid bone marrow evaluation when an aspirate sample is insufficient for conventional cytogenetic analysis.

Indexed as

Chromosomal microarray analysisMyelodysplastic syndromePeripheral bloodSingle nucleotide polymorphismWhole genome scanning

Identifiers

PMID27298759
PMCPMC4890200
OpenAlexW2351624911

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.