ReviewMaternal health, neonatology and perinatology2016
The timing of umbilical cord clamping at birth: physiological considerations.
Review in Maternal health, neonatology and perinatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04052984 (Delayed Cord Clamping and Early Skin-to-skin Contact in Cesarean Section as Interventions That Promote Exclusive Breastfeeding), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Delayed Cord Clamping and Early Skin-to-skin Contact in Cesarean Section as Interventions That Promote Exclusive Breastfeeding
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Porcine versus bovine surfactant therapy for RDS in preterm neonates: pragmatic meta-analysis and review of physiopathological plausibility of the effects on extra-pulmonary outcomes.Respiratory research · 2020Pooled it
- Initiating resuscitation before umbilical cord clamping in infants with congenital diaphragmatic hernia: a pilot feasibility trial.Archives of disease in childhood. Fetal and neonatal edition · 2020Trial
- Placental transfusion in preterm neonates of 30-33 weeks' gestation: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2018Trial
- Effect and safety of timing of cord clamping on neonatal hematocrit values and clinical outcomes in term infants: A randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2018Trial
- A reduction in large animal research threatens the perinatal translation research pipeline.Pediatric research · 2026Review
- South African midwives' knowledge of the benefits of delayed umbilical cord clamping.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2025Article
- Physiological-Based Cord Clamping: When the Baby Is Ready for Clamping.Neonatology · 2024Review
- Maternal implications of placental transfusion.Seminars in perinatology · 2023Article
- Editorial: Cardio-circulatory support of neonatal transition.Frontiers in pediatrics · 2023Article
- Integrated review of the knowledge, attitudes, and practices of maternity health care professionals concerning umbilical cord clamping.Birth (Berkeley, Calif.) · 2022Review
- Article
- Effect of breathing on venous return during delayed cord clamping: an observational study.Archives of disease in childhood. Fetal and neonatal edition · 2022Observational
- Effects of spontaneous first breath on placental transfusion in term neonates born by cesarean section: A randomized controlled trial.Frontiers in pediatrics · 2022Article
- Ex utero intrapartum therapy in infants with congenital diaphragmatic hernia: a propensity score matching analysis.World journal of pediatric surgery · 2022Article
- Article
- Respiratory support after delayed cord clamping: a prospective cohort study of at-risk births at ≥35Archives of disease in childhood. Fetal and neonatal edition · 2021Article
- In utero fetal left ventricular rupture and pseudoaneurysm formation: a case report.BMC pregnancy and childbirth · 2021Article
- Efficacy of Intact Cord Resuscitation Compared to Immediate Cord Clamping on Cardiorespiratory Adaptation at Birth in Infants with Isolated Congenital Diaphragmatic Hernia (CHIC).Children (Basel, Switzerland) · 2021Article
- Effect of maternal oxytocin on umbilical venous and arterial blood flows during physiological-based cord clamping in preterm lambs.PloS one · 2021Article
- The Association Between Placental Residual Blood Volume and Two Placental Transfusion Methods After Delivery at Term.Frontiers in pediatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
While it is now recognized that umbilical cord clamping (UCC) at birth is not necessarily an innocuous act, there is still much confusion concerning the potential benefits and harms of this common procedure. It is most commonly assumed that delaying UCC will automatically result in a time-dependent net placental-to-infant blood transfusion, irrespective of the infant's physiological state. Whether or not this occurs, will likely depend on the infant's physiological state and not on the amount of time that has elapsed between birth and umbilical cord clamping (UCC). However, we believe that this is an overly simplistic view of what can occur during delayed UCC and ignores the benefits associated with maintaining the infant's venous return and cardiac output during transition. Recent experimental evidence and observations in humans have provided compelling evidence to demonstrate that time is not a major factor influencing placental-to-infant blood transfusion after birth. Indeed, there are many factors that influence blood flow in the umbilical vessels after birth, which depending on the dominating factors could potentially result in infant-to-placental blood transfusion. The most dominant factors that influence umbilical artery and venous blood flows after birth are lung aeration, spontaneous inspirations, crying and uterine contractions. It is still not entirely clear whether gravity differentially alters umbilical artery and venous flows, although the available data suggests that its influence, if present, is minimal. While there is much support for delaying UCC at birth, much of the debate has focused on a time-based approach, which we believe is misguided. While a time-based approach is much easier and convenient for the caregiver, ignoring the infant's physiology during delayed UCC can potentially be counter-productive for the infant.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.