ArticleBMC obesity2016
Hormonal regulatory mechanisms in obese children and adolescents after previous weight reduction with a lifestyle intervention: maintain - paediatric part - a RCT from 2009-15.
Article in BMC obesity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00850629 (Hormonal Regulation of Body Weight Maintenance), which is not on this map. Cited by 6 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hormonal Regulation of Body Weight Maintenance
Who cites it
6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight.The Cochrane database of systematic reviews · 2018Pooled it
- Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight.The Cochrane database of systematic reviews · 2018Pooled it
- Diet, physical activity and behavioural interventions for the treatment of overweight or obese children from the age of 6 to 11 years.The Cochrane database of systematic reviews · 2017Pooled it
- Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength.International journal of molecular sciences · 2020Trial
- Dietary Patterns in Adolescent Obesity as Predictors of Long-Term Success Following an Intensive Inpatient Lifestyle Programme.International journal of environmental research and public health · 2022Article
- Natural Autoimmunity to the Thyroid Hormone Monocarboxylate Transporters MCT8 and MCT10.Biomedicines · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWeight loss improves cardiovascular risk factors and "quality of life". Most therapeutic approaches fail to induce a sustained weight loss and most individuals undergo weight regain. In this paper the comprehensive design of the "MAINTAIN" study, all assessments as well as the one year lifestyle intervention will be outlined in detail. METHODS/
designOne-center randomized controlled trial with seven assessment time points conducted 2009-2015. For the randomization eight groups were distinguished in a list to allocate intervention or control group: Females and males either pre-pubertal or pubertal and with a BMI-SDS under or over 2.5.
settingWeight loss at a residential weight reduction programme Berlin/Brandenburg and intervention at a paediatric outpatient clinic;
participants137 children and adolescents (10 to 17 years).
interventionPARTICIPANTS were randomized after an initial weight loss at a residential weight reduction programme and allocated to intervention (n=65) and control (n=72) conditions. The intervention group received an one-year group multi-professional lifestyle intervention with monthly meetings at the paediatric outpatient obesity clinic. The control group had a free living phase for one year and both groups 48 months follow up.
main outcome measuresPARTICIPANTS who are engaged in monthly intervention meetings will benefit in terms of a sustained weight maintenance. The primary aim is to describe the dynamic of hormonal and metabolic mechanisms counter-balancing sustained weight loss during puberty and adolescence. The secondary aim is to investigate the effect of an intensive family based lifestyle intervention during the weight maintenance period on the endogenous counter-regulation as well as on health related quality of life. The third aim is to establish predictors for successful weight maintenance and risk factors for weight regain in obese children and adolescents. DISCUSSION: Weight maintenance after induced weight loss is one of the most important therapeutic challenges as long as most patients fail to maintain their weight loss. MAINTAIN is the first paediatric RCT addressing in parallel to a RCT in obese adults the course of weight regain after induced weight loss and is embedded in an experimental research consortium in order to also address several molecular mechanisms of weight regain.
trial registrationClinicalTrials NCT00850629, first registration 17 February 2009, verified January 2012, Paediatric part of the interventional study. Ethic proposal approved at 08.04.2009.
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