ArticleJournal of clinical medicine research2016
Toxoplasma gondii Infection and Mixed Anxiety and Depressive Disorder: A Case-Control Seroprevalence Study in Durango, Mexico.
Article in Journal of clinical medicine research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Systematic Review on the Relationship between Toxoplasmosis and Mental Disorders.Actas espanolas de psiquiatria · 2024Pooled it
- Relationship between toxoplasmosis and obsessive compulsive disorder: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2019Pooled it
- Is there any association between Toxoplasma gondii infection and depression? A systematic review and meta-analysis.PloS one · 2019Pooled it
- Acod1/itaconate axis controls anxiety-like behaviors induced by chronic infection of Toxoplasma gondii in mice.PLoS neglected tropical diseases · 2026Article
- Pregnant Women Chronically Infected byPathogens (Basel, Switzerland) · 2025Article
- Association between Toxoplasma gondii exposure and abdominal pain: An age- and gender-matched case-control seroprevalence study.European journal of microbiology & immunology · 2024Article
- Association between ABO and Rh blood groups and Toxoplasma gondii infection: A cross sectional study.European journal of microbiology & immunology · 2024Article
- Toxoplasma gondii infection of the central nervous system and suicide: A case-control study of decedents.European journal of microbiology & immunology · 2023Article
- Global seroprevalence ofHealth science reports · 2023Article
- Seroprevalence of Toxoplasma gondii infection among patients of a tertiary hospital in Guangzhou, Guangdong province, PR China.PloS one · 2023Article
- Survey on the association between Toxoplasma gondii infection and violent behavior in inmates.PloS one · 2023Article
- Association between Toxoplasma gondii infection and psychiatric disorders: a cross-sectional study in China.Scientific reports · 2022Article
- Article
- IsPathogens (Basel, Switzerland) · 2021Article
- Association betweenPathogens (Basel, Switzerland) · 2021Article
- Examining the Relationship betweenPathogens (Basel, Switzerland) · 2021Article
- Association between Suicide andPathogens (Basel, Switzerland) · 2021Article
- Article
- Association betweenPathogens (Basel, Switzerland) · 2021Article
- Association between Toxoplasma gondii infection and thyroid dysfunction: a case-control seroprevalence study.BMC infectious diseases · 2019Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe parasite Toxoplasma gondii (T. gondii) may invade the brain and might induce behavioral changes. We sought to determine the association of T. gondii infection and mixed anxiety and depressive disorder.
methodsThrough an age- and gender-matched case-control seroprevalence study, we examined 65 patients suffering from mixed anxiety and depressive disorder (WHO ICD-10 code: F41.2) attending in a public hospital of mental health and 260 control subjects without this disorder from the general population. Sera of participants were analyzed for anti-Toxoplasma IgG and IgM antibodies using enzyme-linked immunoassays.
resultsFifteen (23.1%) of the 65 patients and 18 (6.9%) of the 260 controls had anti-T. gondii IgG antibodies (odds ratio (OR): 4.03; 95% confidence interval (CI): 1.90 - 8.53; P < 0.001). The frequency of high (> 150 IU/mL) anti-T. gondii IgG levels was similar in cases and controls (OR: 0.25; 95% CI: 0.05 - 1.06; P = 0.05). Seroprevalence was similar in male cases and controls (P = 1.0); however, seroprevalence was significantly higher in female cases than in female controls (OR: 7.08; 95% CI: 2.83 - 17.67; P < 0.00001). Patients aged 31 - 50 years old had a significantly higher seroprevalence of T. gondii infection than controls of the same age group (OR: 21.04; 95% CI: 5.22 - 84.80; P < 0.00001). Anti-T. gondii IgM antibodies were found in four (26.7%) of the 15 anti-T. gondii IgG seropositive cases and in 10 (55.6%) of the 18 anti-T. gondii IgG seropositive controls (P = 0.15).
conclusionsResults support for the first time an association between seropositivity to T. gondii and mixed anxiety and depressive disorder. Further research to confirm this association and to determine the seroepidemiology of T. gondii infection in patients with this disorder is needed.
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