ArticleEXCLI journal2013
Beneficial therapeutic effects of Nigella sativa and/or Zingiber officinale in HCV patients in Egypt.
Article in EXCLI journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Virtual Screening, Molecular Docking and Molecular Dynamics Simulation of Bioactive Compounds from Various Indonesian Medicinal Plants as Potential Inhibitors of Human Papillomavirus Type 16 E6 Protein in Cervical Cancer Development.Tropical life sciences research · 2025Article
- Dietary Interventions, Supplements, and Plant-Derived Compounds for Adjunct Vitiligo Management: A Review of the Literature.Nutrients · 2025Review
- Biomimetic Chitosan-Based Hydrogels for Sustainable Wound Healing With AI/ML Insights.IEEE open journal of engineering in medicine and biology · 2025Article
- Clinical andInfectious disorders drug targets · 2025Review
- An Overview of Possible Beneficial Effects of Black Seeds (Infectious disorders drug targets · 2025Review
- Article
- Effect ofCurrent issues in molecular biology · 2023Review
- Ethnobotanical Survey of Medicinal Plants Used in the Treatment of COVID-19 and Related Respiratory Infections in Ogbomosho South and North Local Government Areas, Oyo State, Nigeria.Plants (Basel, Switzerland) · 2022Article
- The effect ofJournal of diabetes and metabolic disorders · 2022Article
- Mechanistic insights from the review and evaluation of ayurvedic herbal medicines for the prevention and management of COVID-19 patients.Journal of herbal medicine · 2022Article
- Herbal medicine use for the management of COVID-19: A review article.Metabolism open · 2021Article
- Thymoquinone against infectious diseases: Perspectives in recent pandemics and future therapeutics.Iranian journal of basic medical sciences · 2021Review
- Coronavirus disease 2019 and the natural agents: Is there a role for the primary care?Journal of family medicine and primary care · 2021Review
- Antiviral Plants in View of Avicenna's The Canon of Medicine and Modern Medicine Against Common Cold.Advances in experimental medicine and biology · 2021Article
- Medicinal Plants in COVID-19: Potential and Limitations.Frontiers in pharmacology · 2021Article
- Prophetic Medicine-Nigella Sativa (Black cumin seeds) - Potential herb for COVID-19?Journal of pharmacopuncture · 2020Review
- Bioactive Compounds and Bioactivities of Ginger (Foods (Basel, Switzerland) · 2019Review
- Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone.Journal of pharmacopuncture · 2017Review
- SELECTIVE INHIBITION OF HEPATITIS C VIRUS REPLICATION BY ALPHA-ZAM, AAfrican journal of traditional, complementary, and alternative medicines : AJTCAM · 2016Article
- The protective effect of Nigella sativa against liver injury: a review.Iranian journal of basic medical sciences · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis C is a major global health burden and Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. The current study was designed to evaluate the beneficial therapeutic effects of ethanolic extracts of Nigella sativa, Zingiber officinale and their mixture in Egyptian HCV patients. Sixty volunteer patients with proven HCV and fifteen age matched healthy subjects were included in this study. Exclusion criteria included patients on interferon alpha (IFN-α) therapy, infection with hepatitis B virus, drug-induced liver diseases, advanced cirrhosis, hepatocellular carcinoma (HCC) or other malignancies, blood picture abnormalities and major severe illness. Liver function enzymes, albumin, total bilirubin, prothrombin time and concentration, international normalized ratio, alpha fetoprotein and viral load were all assessed at baseline and at the end of the study. Ethanolic extracts of Nigella sativa and Zingiber officinale were prepared and formulated into gelatinous capsules, each containing 500 mg of Nigella sativa and/or Zingiber officinale. Clinical response and incidence of adverse drug reactions were assessed initially, periodically, and at the end of the study. Both extracts as well as their mixture significantly ameliorated the altered viral load, alpha fetoprotein, liver function parameters; with more potent effect for the combined therapy. In conclusion, administration of Nigella sativa and/or Zingiber officinale ethanolic extracts to HCV patients exhibited potential therapeutic benefits via decreasing viral load and alleviating the altered liver function, with more potent effect offered by the mixture.
Indexed as
Identifiers
27298610PMC4904745What OpenQuestion holds
Registered trials
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