ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2016
The physics of stratum corneum lipid membranes.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 67 citations in OpenAlex.
- Usefulness of Low-Resistance Electrodes Used in Iontophoresis to Enhance Skin Permeability of Drugs.Molecules (Basel, Switzerland) · 2026Article
- An Assessment of In Vitro Permeation Testing Finite Dose Methodology.AAPS PharmSciTech · 2026Article
- Scratching the Surface: Lipidomic Profiling of the Stratum Corneum in the Search for Pruritogens in Cholestatic Liver Diseases.Journal of personalized medicine · 2026Review
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- HIV-associated penile anaerobes disrupt epithelial barrier integrity.PLoS pathogens · 2025Article
- Insights into Dermal Permeation of Skin Oil Oxidation Products from Enhanced Sampling Molecular Dynamics Simulation.The journal of physical chemistry. B · 2025Article
- Novel Insights into the Dermal Bioaccessibility and Human Exposure to Brominated Flame Retardant Additives in Microplastics.Environmental science & technology · 2023Article
- Characterisation of the Molecular Mechanism of Permeation of the Prodrug Me-5ALA across the HumanInternational journal of molecular sciences · 2022Article
- Using molecular simulation to understand the skin barrier.Progress in lipid research · 2022Review
- Skin Cleansing without or with Compromise: Soaps and Syndets.Molecules (Basel, Switzerland) · 2022Review
- Cerosomes as skin repairing agent: Mode of action studies with a model stratum corneum layer at liquid/air and liquid/solid interfaces.BBA advances · 2022Article
- Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Methodological Considerations for Lipid and Polar Component Analyses in Human Skin Stratum Corneum.Cell biochemistry and biophysics · 2021Review
- Design and Evaluation of Dissolving Microneedles for Enhanced Dermal Delivery of Propranolol Hydrochloride.Pharmaceutics · 2021Article
- Performance of Choline Geranate Deep Eutectic Solvent as Transdermal Permeation Enhancer: An In Vitro Skin Histological Study.Pharmaceutics · 2021Article
- Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration.Cells · 2020Review
- Predicting Transdermal Fentanyl Delivery Using Mechanistic Simulations for Tailored Therapy.Frontiers in pharmacology · 2020Article
- State of the Art in Stratum Corneum Research. Part II: Hypothetical Stratum Corneum Lipid Matrix Models.Skin pharmacology and physiology · 2020Review
- Preferential arrangement of lipids in the long-periodicity phase of a stratum corneum matrix model.Journal of lipid research · 2018Article
- Theoretical investigations into the intermolecular hydrogen-bonding interactions of N-(hydroxymethyl)acetamide dimers.Journal of molecular modeling · 2018Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The stratum corneum (SC), the outermost layer of skin, comprises rigid corneocytes (keratin-filled dead cells) in a specialized lipid matrix. The continuous lipid matrix provides the main barrier against uncontrolled water loss and invasion of external pathogens. Unlike all other biological lipid membranes (such as intracellular organelles and plasma membranes), molecules in the SC lipid matrix show small hydrophilic groups and large variability in the length of the alkyl tails and in the numbers and positions of groups that are capable of forming hydrogen bonds. Molecular simulations provide a route for systematically probing the effects of each of these differences separately. In this article, we present the results from atomistic molecular dynamics of selected lipid bilayers and multi-layers to probe the effect of these polydispersities. We address the nature of the tail packing in the gel-like phase, the hydrogen bond network among head groups, the bending moduli expected for leaflets comprising SC lipids and the conformation of very long ceramide lipids in multi-bilayer lipid assemblies.This article is part of the themed issue 'Soft interfacial materials: from fundamentals to formulation'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.