ArticleProceedings of the National Academy of Sciences of the United States of America2016
Cross-hemispheric dopamine projections have functional significance.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Preservation of Extracellular and Tissue Dopamine During Tyrosine Hydroxylase Loss in Rat 6-OHDA Parkinson's Model: Selective Compensation Restricted to Substantia Nigra.International journal of molecular sciences · 2026Article
- Potential role of SLC6A3 in neurodevelopmental impairments associated with corpus callosum abnormalities: insights from CNV analysis and clinical phenotyping.Molecular cytogenetics · 2025Article
- Dopamine neuron activity encodes the length of upcoming contralateral movement sequences.Current biology : CB · 2024Article
- Characterization of striatal dopamine projections across striatal subregions in behavioral flexibility.The European journal of neuroscience · 2023Article
- Distinct limbic dopamine regulation across olfactory-tubercle subregions through integration of in vivo fast-scan cyclic voltammetry and optogenetics.Journal of neurochemistry · 2022Article
- Simultaneous fMRI and fast-scan cyclic voltammetry bridges evoked oxygen and neurotransmitter dynamics across spatiotemporal scales.NeuroImage · 2021Article
- The cross-hemispheric nigrostriatal pathway prevents the expression of levodopa-induced dyskinesias.Neurobiology of disease · 2021Article
- Impaired reach-to-grasp kinematics in parkinsonian patients relates to dopamine-dependent, subthalamic beta bursts.NPJ Parkinson's disease · 2021Article
- Bidirectional Control of Alcohol-drinking Behaviors Through Locus Coeruleus Optoactivation.Neuroscience · 2020Article
- Frequency- and State-Dependent Network Effects of Electrical Stimulation Targeting the Ventral Tegmental Area in Macaques.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Heterogeneity in striatal dopamine circuits: Form and function in dynamic reward seeking.Journal of neuroscience research · 2020Review
- Opposite Consequences of Tonic and Phasic Increases in Accumbal Dopamine on Alcohol-Seeking Behavior.iScience · 2020Article
- Stereotyped, automatized and habitual behaviours: are they similar constructs under the control of the same cerebral areas?AIMS neuroscience · 2020Review
- Neuromodulators and Long-Term Synaptic Plasticity in Learning and Memory: A Steered-Glutamatergic Perspective.Brain sciences · 2019Review
- Intracerebroventricular injection of ouabain causes mania-like behavior in mice through D2 receptor activation.Scientific reports · 2019Article
- Electrochemistry at the Synapse.Annual review of analytical chemistry (Palo Alto, Calif.) · 2019Review
- In Vivo Phenotyping of Familial Parkinson's Disease with Human Induced Pluripotent Stem Cells: A Proof-of-Concept Study.Neurochemical research · 2019Article
- Real-Time Accumbal Dopamine Response to Negative Stimuli: Effects of Ethanol.ACS chemical neuroscience · 2019Article
- A simplified LED-driven switch for fast-scan controlled-adsorption voltammetry instrumentation.HardwareX · 2019Article
- Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson's disease.Journal of neuroscience research · 2019Article
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Authors and funding
7 authors.
Funding
Abstract
Dopamine signaling occurs on a subsecond timescale, and its dysregulation is implicated in pathologies ranging from drug addiction to Parkinson's disease. Anatomic evidence suggests that some dopamine neurons have cross-hemispheric projections, but the significance of these projections is unknown. Here we report unprecedented interhemispheric communication in the midbrain dopamine system of awake and anesthetized rats. In the anesthetized rats, optogenetic and electrical stimulation of dopamine cells elicited physiologically relevant dopamine release in the contralateral striatum. Contralateral release differed between the dorsal and ventral striatum owing to differential regulation by D2-like receptors. In the freely moving animals, simultaneous bilateral measurements revealed that dopamine release synchronizes between hemispheres and intact, contralateral projections can release dopamine in the midbrain of 6-hydroxydopamine-lesioned rats. These experiments are the first, to our knowledge, to show cross-hemispheric synchronicity in dopamine signaling and support a functional role for contralateral projections. In addition, our data reveal that psychostimulants, such as amphetamine, promote the coupling of dopamine transients between hemispheres.
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