Evidence map›Paper›PMID 27298073›Full record

ArticleMagnetic resonance in medicine2017

Combining hyperpolarized

Michael A Ohliger, Cornelius von Morze, Irene Marco-Rius, Jeremy Gordon, Peder E Z Larson, Robert Bok, Hsin-Yu Chen, John Kurhanewicz, Daniel Vigneron

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Hyperpolarized carbon 13 MRI in liver diseases: Recent advances and future opportunities.Liver international : official journal of the International Association for the Study of the Liver · 2022
    Review
  2. Review
  3. Probing hepatic metabolism of [2-Magma (New York, N.Y.) · 2021
    Article
  4. Hyperpolarized Carbon (Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  5. Role of GdOncology letters · 2020
    Article
  6. HyperpolarizedNMR in biomedicine · 2019
    Article
  7. HyperpolarizedRadiology · 2019
    Review
  8. Article
  9. Detecting liver injury non-invasively using hyperpolarizedLiver international : official journal of the International Association for the Study of the Liver · 2018
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Michael A OhligerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Cornelius von MorzeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Irene Marco-RiusDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Jeremy GordonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0003-4183-3634
Robert BokDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Hsin-Yu ChenDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
John KurhanewiczDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Daniel VigneronDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
University of California, San Francisco · US

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Development and Translation of Hyperpolarized C-13 Prostate Cancer MRI MethodsR01EB017449 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2013 to 2017
$5.9M
Translating HP 13C MRI as a Novel Paradigm for Assessing Drug Target InhibitionR01CA183071 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HURD, RALPH EUGENE, MUNSTER, PAMELA N. · 2014 to 2018
$3.3M
New Instrumentation and Techniques for Hyperpolarized Metabolic and Perfusion MRIR01EB013427 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2013 to 2016
$2.8M
Hyperpolarized C-13 Diffusion MRI Measures of Cellular Transport and MetabolismR01EB016741 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARSON, PEDER ERIC ZUFALL · 2014 to 2017
$2.0M
Molecular Imaging of Renal Transport and Metabolism using Hyperpolarized C-13 MRIK01DK099451 · NIDDK · WASHINGTON UNIVERSITY · PI VON MORZE, CORNELIUS · 2014 to 2018
$820k
NCI NIH HHS R01 CA183071NIBIB NIH HHS P41 EB013598NIBIB NIH HHS R01 EB013427NIBIB NIH HHS R01 EB016741NIBIB NIH HHS R01 EB017449NIDDK NIH HHS K01 DK099451NIDDK NIH HHS P30 DK026743
6 · The paper itself

Abstract

purposeHyperpolarized

methodsBaseline gadoxetate uptake kinetics were measured using T

resultsOverall, the hyperpolarized signal decreased approximately 60% as a result of pre-injection of gadoxetate. In liver, the lactate:pyruvate and alanine:pyruvate ratios decreased 42% and 78%, respectively (P < 0.05) following gadoxetate administration. In kidneys, these ratios did not change significantly. Relaxivity of gadoxetate for [1-

conclusionsThe liver-specific gadolinium contrast-agent gadoxetate can selectively suppress normal hepatocyte contributions to hyperpolarized

Indexed as

AnimalsCarbon-13 Magnetic Resonance SpectroscopyCarbon IsotopesDrug CombinationsGadolinium DTPAHepatocytesLiverMagnetic Resonance ImagingMolecular ImagingRatsRats, Sprague-DawleyReproducibility of ResultsSensitivity and SpecificityCarbon-13Carbon IsotopesDrug CombinationsGadolinium DTPAgadolinium ethoxybenzyl DTPAgadoxetatehyperpolarized carbonlivermetabolismpyruvate

Identifiers

PMID27298073
PMCPMC5156580
OpenAlexW2434544663

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.