ArticleScientific reports2016
AtDOF5.4/OBP4, a DOF Transcription Factor Gene that Negatively Regulates Cell Cycle Progression and Cell Expansion in Arabidopsis thaliana.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 67 citations in OpenAlex.
- Comprehensive analysis of DOF transcription factors and characterization of PlOBP4 during herbaceous peony bud dormancy.Plant cell reports · 2026Article
- DOF gene family in P. sativum (L.): comprehensive genomic identification, phylogenetic examination, evolutionary growth, and expression analysis.BMC genomics · 2025Article
- Dissecting the role of strigolactone perception in barley tolerance to cadmium or zinc stress based on the receptor mutant analysis.BMC plant biology · 2025Article
- Mechanism and Application of Developmental Factors in Plant Genetic Transformation.International journal of molecular sciences · 2025Review
- Genetic and histological characterization of a dwarf mutant in melon (Cucumis melo L.) reveals potential for breeding semi-dwarf cultivars.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Sulfate Deficiency-Responsive MicroRNAs in Tomato Uncover an Expanded and Functionally Integrated Regulatory Network.International journal of molecular sciences · 2025Article
- Genome-Wide Analysis of theInternational journal of molecular sciences · 2025Article
- Integrated endogenous hormones and transcriptome analysis contribute to fruit development related gene mining in Eriobotrya japonica.Scientific reports · 2025Article
- Identification and functional analysis of the Dof transcription factor genes in sugar beet.Journal of plant research · 2025Article
- Genome-Wide Identification of theInternational journal of molecular sciences · 2024Article
- The NAC056 transcription factor confers freezing tolerance by positively regulating expression of CBFs and NIA1 in Arabidopsis.Plant communications · 2024Article
- Identification of Dof transcription factors inFrontiers in genetics · 2024Article
- DOF gene family expansion and diversification.Genetics and molecular biology · 2024Article
- Article
- DNA-Binding One Finger Transcription FactorInternational journal of molecular sciences · 2023Article
- DOF transcription factors: Specific regulators of plant biological processes.Frontiers in plant science · 2023Review
- Sweet potato NAC transcription factorFrontiers in plant science · 2023Article
- Genome-Wide Identification and Analysis ofGenes · 2022Article
- Comparative transcriptomics identifies candidate genes involved in the evolutionary transition from dehiscent to indehiscent fruits in Lepidium (Brassicaceae).BMC plant biology · 2022Article
- The nitrate-inducible NAC transcription factor NAC056 controls nitrate assimilation and promotes lateral root growth in Arabidopsis thaliana.PLoS genetics · 2022Article
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4 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In contrast to animals, plant development involves continuous organ formation, which requires strict regulation of cell proliferation. The core cell cycle machinery is conserved across plants and animals, but plants have developed new mechanisms that precisely regulate cell proliferation in response to internal and external stimuli. Here, we report that the DOF transcription factor OBP4 negatively regulates cell proliferation and expansion. OBP4 is a nuclear protein. Constitutive and inducible overexpression of OBP4 reduced the cell size and number, resulting in dwarf plants. Inducible overexpression of OBP4 in Arabidopsis also promoted early endocycle onset and inhibited cell expansion, while inducible overexpression of OBP4 fused to the VP16 activation domain in Arabidopsis delayed endocycle onset and promoted plant growth. Furthermore, gene expression analysis showed that cell cycle regulators and cell wall expansion factors were largely down-regulated in the OBP4 overexpression lines. Short-term inducible analysis coupled with in vivo ChIP assays indicated that OBP4 targets the CyclinB1;1, CDKB1;1 and XTH genes. These results strongly suggest that OBP4 is a negative regulator of cell cycle progression and cell growth. These findings increase our understanding of the transcriptional regulation of the cell cycle in plants.
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