ArticleScientific reports2016
Broad-spectrum resistance to Bacillus thuringiensis toxins by western corn rootworm (Diabrotica virgifera virgifera).
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Sequential evolution of resistance by western corn rootworm to multipleProceedings of the National Academy of Sciences of the United States of America · 2025Pooled it
- Corn rootworm (Coleoptera: Chrysomelidae) emergence patterns, survival, and injury in blended refuges and pure stands of short-stature corn and tall corn.Pest management science · 2026Article
- Commercial planting of genetically modified maize lowers pest damage, yield loss and pesticide usage in Northeast China.Pest management science · 2026Article
- Molecular mechanisms and comparative transcriptomics of diapause in two corn rootworm species (Current research in insect science · 2025Article
- Knockdown of an ATP-binding cassette transporter in resistant western corn rootworm larvae partially reverses resistance to eCry3.1Ab protein.Scientific reports · 2024Article
- Article
- Genetically modified DP915635 maize is agronomically and compositionally comparable to non-genetically modified maize.GM crops & food · 2023Article
- Review
- Structural journey of an insecticidal protein against western corn rootworm.Nature communications · 2023Article
- Inheritance and Fitness Costs of Laboratory-Selected Resistance to Gpp34/Tpp35Ab1 Corn in Western Corn Rootworm (Coleoptera: Chrysomelidae).Journal of economic entomology · 2023Article
- Article
- Article
- Reduced susceptibility of western corn rootworm (Diabrotica virgifera virgifera LeConte) populations to Cry34/35Ab1-expressing maize in northeast Nebraska.Scientific reports · 2022Article
- Chromobacterium Csp_P biopesticide is toxic to larvae of three Diabrotica species including strains resistant to Bacillus thuringiensis.Scientific reports · 2022Article
- Toxicometabolomic profiling of resistant and susceptible western corn rootworm larvae feeding on Bt maize seedlings.Scientific reports · 2022Article
- RNAi for Western Corn Rootworm Management: Lessons Learned, Challenges, and Future Directions.Insects · 2022Review
- Article
- Development of a nondiapausing strain of northern corn rootworm with rearing techniques for both diapausing and nondiapausing strains.Scientific reports · 2021Article
- Article
- The Essential and Enigmatic Role of ABC Transporters in Bt Resistance of Noctuids and Other Insect Pests of Agriculture.Insects · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolution of resistance and cross-resistance threaten the sustainability of genetically engineered crops that produce insecticidal toxins derived from the bacterium Bacillus thuringiensis (Bt). Western corn rootworm, Diabrotica virgifera virgifera LeConte, is a serious pest of maize and has been managed with Bt maize since 2003. We conducted laboratory bioassays with maize hybrids producing Bt toxins Cry3Bb1, mCry3A, eCry3.1Ab, and Cry34/35Ab1, which represent all commercialized Bt toxins for management of western corn rootworm. We tested populations from fields where severe injury to Cry3Bb1 maize was observed, and populations that had never been exposed to Bt maize. Consistent with past studies, bioassays indicated that field populations were resistant to Cry3Bb1 maize and mCry3A maize, and that cross-resistance was present between these two types of Bt maize. Additionally, bioassays revealed resistance to eCry3.1Ab maize and cross-resistance among Cry3Bb1, mCry3A and eCry3.1Ab. However, no resistance or cross-resistance was detected for Cry34/35Ab1 maize. This broad-spectrum resistance illustrates the potential for insect pests to develop resistance rapidly to multiple Bt toxins when structural similarities are present among toxins, and raises concerns about the long-term durability of Bt crops for management of some insect pests.
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