ArticleTranslational stroke research2016
Phase III Preclinical Trials in Translational Stroke Research: Community Response on Framework and Guidelines.
Article in Translational stroke research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Pooled it
- Pooled it
- National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research.Intensive care medicine experimental · 2021Article
- The Impact of Voluntary Exercise on Stroke Recovery.Frontiers in neuroscience · 2021Article
- Predicting experimental success: a retrospective case-control study using the rat intraluminal thread model of stroke.Disease models & mechanisms · 2020Article
- Potential of Exosomes for the Treatment of Stroke.Cell transplantation · 2019Review
- Effects of Female Sex Steroids Administration on Pathophysiologic Mechanisms in Traumatic Brain Injury.Translational stroke research · 2018Review
- To Improve Translational Research in Subarachnoid Hemorrhage.Translational stroke research · 2018Article
- Translational Stroke Research Guideline Projections: The 20/20 Standards.Translational stroke research · 2018Article
- Review
- Precision Stroke Animal Models: the Permanent MCAO Model Should Be the Primary Model, Not Transient MCAO.Translational stroke research · 2017Article
- Can Quality Improvement Tools Overcome the Translational Roadblock-the Vital Influence of the Researcher.Translational stroke research · 2017Article
- Correcting the Trajectory of Stroke Therapeutic Research.Translational stroke research · 2017Article
- BMP4/LIF or RA/Forskolin Suppresses the Proliferation of Neural Stem Cells Derived from Adult Monkey Brain.Stem cells international · 2017Article
- A specific dietary intervention to restore brain structure and function after ischemic stroke.Theranostics · 2017Article
- Recent progress in translational research on neurovascular and neurodegenerative disorders.Restorative neurology and neuroscience · 2017Review
- Challenges and Controversies in Translational Stroke Research - an Introduction.Translational stroke research · 2016Article
- Academic-industry Collaborations in Translational Stroke Research.Translational stroke research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The multicenter phase III preclinical trial concept is currently discussed to enhance the predictive value of preclinical stroke research. After public announcement, we collected a community feedback on the concept with emphasis on potential design features and guidelines by an anonymous survey. Response analysis was conducted after plausibility checks by applying qualitative and quantitative measures. Most respondents supported the concept, including the implementation of a centralized steering committee. Based on received feedback, we suggest careful, stepwise implementation and to leave selected competencies and endpoint analysis at the discretion of participating centers. Strict application of quality assurance methods is accepted, but should be harmonized. However, received responses also indicate that the application of particular quality assurance models may require more attention throughout the community. Interestingly, clear and pragmatic preferences were given regarding publication and financing, suggesting the establishing of writing committees similar to large-scale clinical trials and global funding resources for financial support. The broad acceptance among research community encourages phase III preclinical trial implementation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.