ArticleNature communications2016
Calredoxin represents a novel type of calcium-dependent sensor-responder connected to redox regulation in the chloroplast.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Linking redox and calcium signaling via thioredoxins.Journal of experimental botany · 2026Review
- Calcium signaling in crops.The New phytologist · 2026Review
- Diatoms exhibit dynamic chloroplast calcium signals in response to high light and oxidative stress.Plant physiology · 2024Article
- Aggregation-Induced Emission Photosensitizer Boosting Algal Growth and Lipid Accumulation.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Regulation of Microalgal Photosynthetic Electron Transfer.Plants (Basel, Switzerland) · 2024Review
- Calredoxin regulates the chloroplast NADPH-dependent thioredoxin reductase in Chlamydomonas reinhardtii.Plant physiology · 2023Article
- Temporal and thermal profiling of theeLife · 2022Article
- The Chlamydomonas bZIP transcription factor BLZ8 confers oxidative stress tolerance by inducing the carbon-concentrating mechanism.The Plant cell · 2022Article
- Chlamydomonas as a model for reactive oxygen species signaling and thiol redox regulation in the green lineage.Plant physiology · 2021Review
- A chloroplast redox relay adapts plastid metabolism to light and affects cytosolic protein quality control.Plant physiology · 2021Article
- Chlamydomonas reinhardtii cellular compartments and their contribution to intracellular calcium signalling.Journal of experimental botany · 2021Review
- The In Vitro Interaction of 12-Oxophytodienoic Acid and Related Conjugated Carbonyl Compounds with Thiol Antioxidants.Biomolecules · 2021Article
- Exploring the Functional Relationship betweenAntioxidants (Basel, Switzerland) · 2020Article
- Calcium sensing via EF-hand 4 enables thioredoxin activity in the sensor-responder protein calredoxin in the green algaThe Journal of biological chemistry · 2020Article
- Light-dependent N-terminal phosphorylation of LHCSR3 and LHCB4 are interlinked in Chlamydomonas reinhardtii.The Plant journal : for cell and molecular biology · 2019Article
- Chloroplast thioredoxin systems dynamically regulate photosynthesis in plants.The Biochemical journal · 2019Review
- Chloroplast Redox Regulatory Mechanisms in Plant Adaptation to Light and Darkness.Frontiers in plant science · 2019Review
- Cellular CaThe Plant cell · 2018Article
- Configuration of Ten Light-Harvesting ChlorophyllPlant physiology · 2018Article
- Gordon Research Conference on photosynthesis: photosynthetic plasticity from the environment to synthetic systems.Photosynthesis research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium (Ca(2+)) and redox signalling play important roles in acclimation processes from archaea to eukaryotic organisms. Herein we characterized a unique protein from Chlamydomonas reinhardtii that has the competence to integrate Ca(2+)- and redox-related signalling. This protein, designated as calredoxin (CRX), combines four Ca(2+)-binding EF-hands and a thioredoxin (TRX) domain. A crystal structure of CRX, at 1.6 Å resolution, revealed an unusual calmodulin-fold of the Ca(2+)-binding EF-hands, which is functionally linked via an inter-domain communication path with the enzymatically active TRX domain. CRX is chloroplast-localized and interacted with a chloroplast 2-Cys peroxiredoxin (PRX1). Ca(2+)-binding to CRX is critical for its TRX activity and for efficient binding and reduction of PRX1. Thereby, CRX represents a new class of Ca(2+)-dependent 'sensor-responder' proteins. Genetically engineered Chlamydomonas strains with strongly diminished amounts of CRX revealed altered photosynthetic electron transfer and were affected in oxidative stress response underpinning a function of CRX in stress acclimation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.