ArticleScientific reports2016
Visible to near-infrared refractive properties of freshly-excised human-liver tissues: marking hepatic malignancies.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
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- Real Index of Refraction of Normal and Cancerous Axillary Lymph Nodes in Breast Cancer Patients: Results from an Experimental Study.Journal of personalized medicine · 2025Article
- Optimized intravital three-photon imaging of intact mouse tibia links plasma cell motility to functional states.iScience · 2024Article
- Refractiveindex.info database of optical constants.Scientific data · 2024Article
- Optical Imaging in Human Lymph Node Specimens for Detecting Breast Cancer Metastases: A Review.Cancers · 2023Review
- Highly sensitive label-free biosensor: graphene/CaFScientific reports · 2023Article
- Effect of nanoshell geometries, sizes, and quantum emitter parameters on the sensitivity of plasmon-exciton hybrid nanoshells for sensing application.Scientific reports · 2023Article
- Fractal-based aberration-corrected full-field OCT.Biomedical optics express · 2023Article
- Rapid and label-free histological imaging of unprocessed surgical tissues via dark-field reflectance ultraviolet microscopy.iScience · 2023Article
- Measurement of tissue optical properties in a wide spectral range: a review [Invited].Biomedical optics express · 2023Review
- Optical characterization of the liver tissue affected by fibrolamellar hepatocellular carcinoma based on internal filters of laser-induced fluorescence.Scientific reports · 2022Article
- Predictions of cervical cancer identification by photonic method combined with machine learning.Scientific reports · 2022Article
- Article
- Engineered nano-sphere array of gold-DNA core-shells and junctions as opto-plasmonic sensors for biodetection.RSC advances · 2021Article
- Annular Fiber Probe for Interstitial Illumination in Photoacoustic Guidance of Radiofrequency Ablation.Sensors (Basel, Switzerland) · 2021Article
- Optical percutaneous needle biopsy of the liver: a pilot animal and clinical study.Scientific reports · 2020Article
- 2D Nanomaterial-Based Surface Plasmon Resonance Sensors for Biosensing Applications.Micromachines · 2020Review
- Evaluation of UVA emission from x-ray megavoltage-irradiated tissues and phantoms.Physics in medicine and biology · 2019Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The refractive index is an optical constant that plays a significant role in the description of light-matter interactions. When it comes to biological media, refraction is understudied despite recent advances in the field of bio-optics. In the present article, we report on the measurement of the refractive properties of freshly excised healthy and cancerous human liver samples, by use of a prism-coupling technique covering the visible and near-infrared spectral range. Novel data on the wavelength-dependent complex refractive index of human liver tissues are presented. The magnitude of the real and imaginary part of the refractive index is correlated with hepatic pathology. Notably, the real index contrast is pointed out as a marker of discrimination between normal liver tissue and hepatic metastases. In view of the current progress in optical biosensor technologies, our findings may be exploited for the development of novel surgical and endoscopic tools.
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