Evidence map›Paper›PMID 27297009›Full record

ArticleBMJ open2016

Latest trends in ADHD drug prescribing patterns in children in the UK: prevalence, incidence and persistence.

Raphaelle Beau-Lejdstrom, Ian Douglas, Stephen J W Evans, Liam Smeeth

Registry-linked trialAbstract read
In one paragraph

Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03817710 (Prevalence of Tics in Childern With Acute Deficit Hyper Activity Syndrom), which is not on this map. Cited by 45 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03817710 unknown statusnot on this mapstarted 2019, after this paper: background citation

Prevalence of Tics in Childern With Acute Deficit Hyper Activity Syndrom

TypeobservationalSponsorAssiut UniversityRan2019 to 2020Enrolled100ConditionsBehavior Disorders
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  8. Self-directed speech and attention deficit hyperactive disorder-like behaviours.British journal of psychology (London, England : 1953) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Raphaelle Beau-LejdstromInstitute of Global Health, University of Geneva, Geneva, Switzerland.
Ian DouglasLondon School of Hygiene and Tropical Medicine, London, UK.
Stephen J W EvansLondon School of Hygiene and Tropical Medicine, London, UK.
Liam SmeethLondon School of Hygiene and Tropical Medicine, London, UK.

Funding

Medical Research Council G0802403Medical Research Council MR/K006584/1Wellcome Trust
6 · The paper itself

Abstract

objectivesTo investigate attention deficit and hyperactivity disorder (ADHD) drug prescribing in children under 16 years old in the UK between 1992 and 2013.

methodsAll patients under 16 registered in the Clinical Practice Research Datalink (CPRD) with a minimum of 1 year of observation time and who received at least one prescription of any ADHD drug between 1 January 1992 and 31 December 2013.Trends in prevalence and incidence of use of ADHD drugs in children were calculated between 1995 and 2013 and persistence in new users was estimated.

resultsThe prevalence of ADHD drug use in children under 16 increased 34-fold overall, rising from 1.5 95% CI (1.1 to 2.0) per 10 000 children in 1995 to 50.7 95% CI (49.2 to 52.1) per 10 000 children in 2008 then stabilising to 51.1 95% CI (49.7 to 52.6) per 10 000 children in 2013. The rate of new users increased eightfold reaching 10.2 95% CI (9.5 to 10.9) per 10 000 children in 2007 then decreasing to 9.1 95% CI (8.5 to 9.7) per 10 000 children in 2013. Although prevalence and incidence increased rather steeply after 1995, this trend seems to halt from 2008 onwards. We identified that 77%, 95% CI (76% to 78%) of children were still under treatment after 1 year and 60% 95% CI (59% to 61%) after 2 years.

conclusionsThere was a marked increase in ADHD drug use among children in the UK from 1992 until around 2008, with stable levels of use since then. UK children show relatively long persistence of treatment with ADHD medications compared to other countries.

Indexed as

AdolescentAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildChild, PreschoolDrug PrescriptionsFemaleHumansIncidenceKaplan-Meier EstimateMaleMethylphenidatePractice Patterns, Physicians'PrevalenceProportional Hazards ModelsRegistriesCentral Nervous System StimulantsMethylphenidateattention deficit and hyperactivity disorderattention deficit and hyperactivity disorder drugsMedication trendsMedication usepaediatric mental health

Identifiers

PMID27297009
PMCPMC4932306

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.