ArticleScientific reports2016
Virulence determinants associated with the Asian community-associated methicillin-resistant Staphylococcus aureus lineage ST59.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
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- Genome-based surveillance reveals cross-transmission of MRSA ST59 between humans and retail livestock products in Hanzhong, China.Frontiers in microbiology · 2024Article
- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
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- The genetic feature and virulence determinant of highly virulent community-associated MRSA ST338-SCCmec Vb in China.Emerging microbes & infections · 2021Article
- Pathogenicity and virulence ofVirulence · 2021Review
- Drivers of methicillin-resistant Staphylococcus aureus (MRSA) lineage replacement in China.Genome medicine · 2021Article
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- Interaction between Staphylococcus Agr virulence and neutrophils regulates pathogen expansion in the skin.Cell host & microbe · 2021Article
- Contribution of Staphylococcal Enterotoxin B to Staphylococcus aureus Systemic Infection.The Journal of infectious diseases · 2021Article
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- Comparative Analysis of Virulence and Toxin Expression of Vancomycin-Intermediate and Vancomycin-SensitiveFrontiers in microbiology · 2020Article
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Authors and funding
14 authors.
Funding
Abstract
Understanding virulence is vital for the development of novel therapeutics to target infections with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), which cause an ongoing epidemic in the United States and are on a global rise. However, what defines virulence particularly of global CA-MRSA lineages is poorly understood. Threatening a vast population, the predominant Asian CA-MRSA lineage ST59 is of major epidemiological importance. However, there have been no molecular analyses using defined virulence gene deletion mutants in that lineage as of yet. Here, we compared virulence in skin, lung, and blood infection models of ST59 CA-MRSA isolates with geographically matched hospital-associated MRSA isolates. We selected a representative ST59 CA-MRSA isolate based on toxin expression and virulence characteristics, and produced isogenic gene deletion mutants of important CA-MRSA virulence determinants (α-toxin, PSM α, Agr) in that isolate for in-vitro and in-vivo analyses. Our results demonstrate strongly enhanced virulence of ST59 CA-MRSA over hospital-associated lineages, supporting the notion that enhanced virulence is characteristic for CA-MRSA. Furthermore, they show strong and significant contribution of Agr, α-toxin, and PSMα to pathogenesis of ST59 CA-MRSA skin, lung, and blood infection, emphasizing the value of drug development efforts targeted toward those virulence determinants.
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