ArticleNature communications2016
High-flexibility combinatorial peptide synthesis with laser-based transfer of monomers in solid matrix material.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Synthetic High-Throughput Microarrays of Peptidoglycan Fragments as a Novel Sero-Diagnostic Tool for Patient Antibody Profiling.Angewandte Chemie (International ed. in English) · 2025Article
- Resemblance-Ranking Peptide Library as a Representation of a Complex Proteome.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Label-Free Imaging of Solid-Phase Peptide Synthesis Products and Their Modifications Tethered in Microspots Using Time-of-Flight Secondary Ion Mass Spectrometry.International journal of molecular sciences · 2023Article
- Screening for Primordial RNA-Peptide Interactions Using High-Density Peptide Arrays.Life (Basel, Switzerland) · 2023Article
- Cutting edge technologies in chronic inflammation research.Experimental dermatology · 2022Review
- Assessing Polymer-Surface Adhesion with a Polymer Collection.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Position Matters: Fluorescent Positional Isomers for Reliable Multichannel Encryption Devices.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Identification of a Zika NS2B epitope as a biomarker for severe clinical phenotypes.RSC medicinal chemistry · 2021Article
- Controlling Surface Wettability for Automated In Situ Array Synthesis and Direct Bioscreening.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Laser-driven growth of structurally defined transition metal oxide nanocrystals on carbon nitride photoelectrodes in milliseconds.Nature communications · 2021Article
- High-throughput determination of protein affinities using unmodified peptide libraries in nanomolar scale.iScience · 2021Article
- Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylases.Nature communications · 2021Article
- Probing Multivalent Carbohydrate-Protein Interactions With On-Chip Synthesized Glycopeptides Using Different Functionalized Surfaces.Frontiers in chemistry · 2021Article
- Rapid Response to Pandemic Threats: Immunogenic Epitope Detection of Pandemic Pathogens for Diagnostics and Vaccine Development Using Peptide Microarrays.Journal of proteome research · 2020Review
- On-Chip Neo-Glycopeptide Synthesis for Multivalent Glycan Presentation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM) · 2020Review
- Stochastic deposition of amino acids into microcavities via microparticles.Scientific reports · 2019Article
- High-density Peptide Arrays Help to Identify Linear Immunogenic B-cell Epitopes in Individuals Naturally Exposed to Malaria Infection.Molecular & cellular proteomics : MCP · 2019Article
- Combinatorial Peptide Microarray Synthesis Based on Microfluidic Impact Printing.ACS combinatorial science · 2019Article
- Enhancing the Microparticle Deposition Stability and Homogeneity on Planer for Synthesis of Self-Assembly Monolayer.Nanomaterials (Basel, Switzerland) · 2018Article
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Authors and funding
22 authors.
Funding
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Abstract
Laser writing is used to structure surfaces in many different ways in materials and life sciences. However, combinatorial patterning applications are still limited. Here we present a method for cost-efficient combinatorial synthesis of very-high-density peptide arrays with natural and synthetic monomers. A laser automatically transfers nanometre-thin solid material spots from different donor slides to an acceptor. Each donor bears a thin polymer film, embedding one type of monomer. Coupling occurs in a separate heating step, where the matrix becomes viscous and building blocks diffuse and couple to the acceptor surface. Furthermore, we can consecutively deposit two material layers of activation reagents and amino acids. Subsequent heat-induced mixing facilitates an in situ activation and coupling of the monomers. This allows us to incorporate building blocks with click chemistry compatibility or a large variety of commercially available non-activated, for example, posttranslationally modified building blocks into the array's peptides with >17,000 spots per cm(2).
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