ArticleBMC infectious diseases2016
Sending repeat cultures: is there a role in the management of bacteremic episodes? (SCRIBE study).
Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Association of Follow-up Blood Cultures With Mortality in Patients With Gram-Negative Bloodstream Infections: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- Frequency and Predictors of Positive Follow-up Blood Cultures in Patients with Streptococcal Bacteremia.Open forum infectious diseases · 2026Trial
- Article
- The association between body temperature parameters and blood culture positivity in the inpatient setting: a retrospective cohort study.BMC infectious diseases · 2026Article
- Factors associated with persistent bloodstream infection in the Neonatal Intensive Care Unit.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Rapid Diagnostic Stewardship and Blood Culture Use in a Pediatric Medical Center.JAMA network open · 2025Article
- Factors associated with persistent bacteraemia among patients with suspected infective endocarditis.Infection · 2025Article
- Early follow-up blood cultures-frequency and outcomes of repeat blood culture collection within 48 hours of emergency department workup: an observational study.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Standardization in the management of gram-negative bloodstream infections after implementation of a clinical care guideline at a large academic, safety-net institution: a quasi-experimental study.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Persistent bloodstream infection in children: examining the role for repeat blood cultures.Journal of clinical microbiology · 2024Article
- Article
- Genomic analysis ofiScience · 2024Article
- Epidemiology and clinical relevance of persistent bacteraemia in patients with Gram-negative bloodstream infection: a retrospective cohort study.The Journal of antimicrobial chemotherapy · 2024Article
- Is It Useful to Repeat Blood Cultures in Endocarditis Patients? A Critical Appraisal.Diagnostics (Basel, Switzerland) · 2024Review
- Culture-independent identification of bloodstream infections from whole blood: prospective evaluation in specimens of known infection status.Journal of clinical microbiology · 2024Article
- Persistence of Detectable Pathogens by Culture-Independent Systems (T2 Magnetic Resonance) in Patients With Bloodstream Infection: Prognostic Role and Possible Clinical Implications.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Observational
- Evaluation of Blood Culture Results in Patients with Malignancy in Erzurum Province, Turkey.Acta medica Lituanic · 2024Article
- Prevalence of blood stream infections and associated factors among febrile neutropenic cancer patients on chemotherapy at Ocean Road Cancer Institute, Tanzania.Infectious agents and cancer · 2023Article
- The effect of follow-up blood cultures on mortality and antibiotic use in gram-negative bloodstream infections.BMC infectious diseases · 2023Article
- Therapeutics for Vancomycin-Resistant Enterococcal Bloodstream Infections.Clinical microbiology reviews · 2023Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the management of bacteremia, positive repeat blood cultures (persistent bacteremia) are associated with increased mortality. However, blood cultures are costly and it is likely unnecessary to repeat them for many patients. We assessed predictors of persistent bacteremia that should prompt repeat blood cultures.
methodsWe conducted a retrospective cohort study of bacteremias at an academic hospital from April 2010 to June 2014. We examined variables associated with patients undergoing repeat blood cultures, and with repeat cultures being positive. A nested case control analysis was performed on a subset of patients with repeat cultures.
resultsAmong 1801 index bacteremias, repeat cultures were drawn for 701 patients (38.9 %), and 118 persistent bacteremias (6.6 %) were detected. Endovascular source (adjusted odds ratio [aOR], 7.66; 95 % confidence interval [CI], 2.30-25.48), epidural source (aOR, 26.99; 95 % CI, 1.91-391.08), and Staphylococcus aureus bacteremia (aOR, 4.49; 95 % CI, 1.88-10.73) were independently associated with persistent bacteremia. Escherichia coli (5.1 %, P = 0.006), viridans group (1.7 %, P = 0.035) and β-hemolytic streptococci (0 %, P = 0.028) were associated with a lower likelihood of persistent bacteremia. Patients with persistent bacteremia were less likely to have achieved source control within 48 h of the index event (29.7 % vs 52.5 %, P < .001), but after variable reduction, source control was not retained in the final multivariable model.
conclusionsPatients with S. aureus bacteremia or endovascular infection are at risk of persistent bacteremia. Achieving source control within 48 h of the index bacteremia may help clear the infection. Repeat cultures after 48 h are low yield for most Gram-negative and streptococcal bacteremias.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.