ArticleScientific reports2016
A comparative genomic analysis of targets of Hox protein Ultrabithorax amongst distant insect species.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Article
- A Micro-evolutionary Change in Target Binding Sites as a Key Determinant of Ultrabithorax Function in Drosophila.Journal of molecular evolution · 2023Article
- A cis-regulatory sequence of the selector gene vestigial drives the evolution of wing scaling in Drosophila species.The Journal of experimental biology · 2023Article
- Overexpression ofInternational journal of molecular sciences · 2023Article
- CRISPR/Cas9-Mediated Mutagenesis ofInsects · 2022Article
- Transcriptome dynamics during metamorphosis of imaginal discs into wings and thoracic dorsum in Apis mellifera castes.BMC genomics · 2021Article
- Hox dosage contributes to flight appendage morphology in Drosophila.Nature communications · 2021Article
- Hox genes are essential for the development of eyespots in Bicyclus anynana butterflies.Genetics · 2021Article
- Roles ofFrontiers in cell and developmental biology · 2021Review
- Article
- The cis-regulatory logic underlying abdominal Hox-mediated repression versus activation of regulatory elements in Drosophila.Developmental biology · 2019Article
- Genome-wide open chromatin regions and their effects on the regulation of silk protein genes in Bombyx mori.Scientific reports · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the fruitfly Drosophila melanogaster, the differential development of wing and haltere is dependent on the function of the Hox protein Ultrabithorax (Ubx). Here we compare Ubx-mediated regulation of wing patterning genes between the honeybee, Apis mellifera, the silkmoth, Bombyx mori and Drosophila. Orthologues of Ubx are expressed in the third thoracic segment of Apis and Bombyx, although they make functional hindwings. When over-expressed in transgenic Drosophila, Ubx derived from Apis or Bombyx could suppress wing development, suggesting evolutionary changes at the level of co-factors and/or targets of Ubx. To gain further insights into such events, we identified direct targets of Ubx from Apis and Bombyx by ChIP-seq and compared them with those of Drosophila. While majority of the putative targets of Ubx are species-specific, a considerable number of wing-patterning genes are retained, over the past 300 millions years, as targets in all the three species. Interestingly, many of these are differentially expressed only between wing and haltere in Drosophila but not between forewing and hindwing in Apis or Bombyx. Detailed bioinformatics and experimental validation of enhancer sequences suggest that, perhaps along with other factors, changes in the cis-regulatory sequences of earlier targets contribute to diversity in Ubx function.
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