ReviewCurrent neuropharmacology2016
Metabotropic Glutamate Receptor Dependent Cortical Plasticity in Chronic Pain.
Review in Current neuropharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Trial
- Crosstalk Between Cortical Plasticity and Peripheral Nervous Injury: Insights, Mechanisms, and Future Directions.CNS neuroscience & therapeutics · 2026Review
- GluK1-containing kainate receptor-dependent long-term depression in the anterior cingulate cortex modulates chronic pain.Journal of translational medicine · 2026Article
- Cortical Potentiation in Chronic Neuropathic Pain and the Future Treatment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Neurochemical crossroads: exploring the neurotransmitter network in chronic pain and depression comorbidity.Frontiers in molecular neuroscience · 2025Review
- The basolateral amygdala-anterior cingulate cortex circuit contributes to postherpetic neuralgia-anxiety comorbidity.Theranostics · 2025Article
- Cortical Tagged Synaptic Long-Term Depression in the Anterior Cingulate Cortex of Adult Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain.The journal of headache and pain · 2024Review
- Ion Channel Disturbances in Migraine Headache: Exploring the Potential Role of the Kynurenine System in the Context of the Trigeminovascular System.International journal of molecular sciences · 2023Review
- Research progress on the mechanism of chronic neuropathic pain.IBRO neuroscience reports · 2023Review
- Review
- Metabolite activity in the anterior cingulate cortex during a painful stimulus using functional MRS.Scientific reports · 2020Article
- Role of Potassium Ions Quantum Tunneling in the Pathophysiology of Phantom Limb Pain.Brain sciences · 2020Article
- Sex difference in synaptic plasticity in the anterior cingulate cortex of adult mice.Molecular brain · 2020Article
- Phantom limb pain: A literature review.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2018Review
- Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice.Biology of reproduction · 2018Article
- Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many cortical areas play crucial roles in higher order brain functions such as pain and emotion-processing, decision-making, and cognition. Among them, anterior cingulate cortex (ACC) and insular cortex (IC) are two key areas. Glutamate mediates major excitatory transmission during long-term plasticity in both physiological and pathological conditions. Specifically related to nociceptive or pain behaviors, metabotropic glutamate subtype receptors (mGluRs) have been involved in different types of synaptic modulation and plasticity from periphery to the spinal cord. However, less is known about their functional roles in plasticity related to pain and its related behaviors within cortical regions. In this review, we first summarized previous studies of synaptic plasticity in both the ACC and IC, and discussed how mGluRs may be involved in both cortical long-term potentiation (LTP) and long-term depression (LTD)-especially in LTD. The activation of mGluRs contributes to the induction of LTD in both ACC and IC areas. The loss of LTD caused by peripheral amputation or nerve injury can be rescued by priming ACC or IC with activations of mGluR1 receptors. We also discussed the potential functional roles of mGluRs for pain-related behaviors. We propose that targeting mGluRs in the cortical areas including the ACC and IC may provide a new therapeutic strategy for the treatment of chronic pain, phantom pain or anxiety.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.