ArticleBMC psychiatry2016
Group cognitive behavioral therapy modulates the resting-state functional connectivity of amygdala-related network in patients with generalized social anxiety disorder.
Article in BMC psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of resting-state fMRI in anxiety disorders: Need for data sharing to move the field forward.Journal of anxiety disorders · 2023Pooled it
- Resting-state neuroimaging in social anxiety disorder: a systematic review.Molecular psychiatry · 2022Pooled it
- Neural correlates of psychodynamic and non-psychodynamic therapies in different clinical populations through fMRI: A meta-analysis and systematic review.Frontiers in human neuroscience · 2022Pooled it
- Low-intensity transcranial focused ultrasound amygdala neuromodulation: a double-blind sham-controlled target engagement study and unblinded single-arm clinical trial.Molecular psychiatry · 2025Trial
- Cognitive Behavioral Therapy for Anxiety in Parkinson's Disease Induces Functional Brain Changes.Journal of Parkinson's disease · 2023Trial
- Resting-state amygdala subregion and precuneus connectivity provide evidence for a dimensional approach to studying social anxiety disorder.Translational psychiatry · 2024Article
- Percutaneous Electrical Nerve Field Stimulation in Children and Adolescents With Functional Dyspepsia-Integrating a Behavioral Intervention.Neuromodulation : journal of the International Neuromodulation Society · 2024Article
- Informing the treatment of social anxiety disorder with computational and neuroimaging data.Psychoradiology · 2024Article
- A brain model of altered self-appraisal in social anxiety disorder.Translational psychiatry · 2023Article
- Intergenerational Transmission of Maternal Childhood Maltreatment Prior to Birth: Effects on Human Fetal Amygdala Functional Connectivity.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Individual cognitive therapy reduces frontal-thalamic resting-state functional connectivity in social anxiety disorder.Frontiers in psychiatry · 2023Article
- Combinatorial approaches for treating neuropsychiatric social impairment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Neurocircuitry of treatment in anxiety disorders.Biomarkers in neuropsychiatry · 2022Article
- Anxiety and amygdala connectivity during movie-watching.Neuropsychologia · 2022Article
- Amygdala connectivity and implications for social cognition and disorders.Handbook of clinical neurology · 2022Review
- Alteration of resting-state functional connectivity network properties in patients with social anxiety disorder after virtual reality-based self-training.Frontiers in psychiatry · 2022Article
- Intrinsic functional connectivity in families genetically enriched for social anxiety disorder - an endophenotype study.EBioMedicine · 2021Article
- Functional Alterations in Cerebellar Functional Connectivity in Anxiety Disorders.Cerebellum (London, England) · 2021Article
- Prevalence and associated factors of depression and anxiety among nurses during the outbreak of COVID-19 in China: A cross-sectional study.International journal of nursing studies · 2021Article
- Association of Intrinsic Brain Architecture With Changes in Attentional and Mood Symptoms During Development.JAMA psychiatry · 2020Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmygdala is considered as the core pathogenesis of generalized social anxiety disorder (GSAD). However, it is still unclear whether effective group cognitive behavioral therapy (CBT) could modulate the function of amygdala-related network. We aimed to examine the resting-state functional connectivity (rsFC) of the amygdala before and after group CBT.
methodsFifteen patients with GSAD were scanned on a 3T MR system before and after 8 weeks of group CBT. For comparison, nineteen healthy control participants also underwent baseline fMRI scanning. We used bilateral amygdala as seed regions and the rsFC maps of the right and left amygdala were created separately in a voxel-wise way. Clusters survived two-tailed Gaussian Random Field (GRF) correction at p <0.05 (voxel z value >2.3).
resultsCompared with baseline, patients with CBT showed significantly decreased connectivity of the left amygdala with the right putamen, the left dorsal medial prefrontal cortex (dmPFC) and the right dorsal anterior cingulate cortex (dACC). Especially, the changes of the connectivity between the left amygdala and the dACC positively correlated with changes of the anxiety symptom in patients. Furthermore, in relative to controls, patients showed higher connectivity of left amygdala with dmPFC and dACC at baseline, while normal after CBT.
conclusionsShort-term group CBT could down-regulate the abnormal higher connectivity of prefrontal-amygdala network, along with clinical improvement. This may provide a potential biomarker to monitor the treatment effect of CBT in GSAD patients.
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