ArticleJournal of tissue engineering and regenerative medicine2017
Reconstitution of full-thickness skin by microcolumn grafting.
Article in Journal of tissue engineering and regenerative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- The Use of Therapeutic Peptides in Combination with Full-Thickness Skin Columns to Improve Healing of Excisional Wounds.Bioengineering (Basel, Switzerland) · 2025Article
- Novel Techniques in Fractional Skin Replacement.European burn journal · 2025Review
- Application of a minimally invasive full-thickness autologous microcolumn skin harvesting device for donor site tissue collection and augmenting wound healing in a porcine wound model.International wound journal · 2024Article
- Structural and molecular characteristics of weight-bearing volar skin can be reconstituted by micro skin tissue column grafting.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Autologous wound margin point columnar full-thickness skin grafting combined with negative pressure wound therapy improves wound healing in refractory diabetic foot ulcers.International wound journal · 2023Article
- Tissue Engineering-Based Strategies for Diabetic Foot Ulcer Management.Advances in wound care · 2023Review
- Injectable multifunctional CMC/HA-DA hydrogel for repairing skin injury.Materials today. Bio · 2022Article
- The Antibiofilm Nanosystems for Improved Infection Inhibition of Microbes in Skin.Molecules (Basel, Switzerland) · 2021Review
- MagneTEskin-Reconstructing skin by magnetically induced assembly of autologous microtissue cores.Science advances · 2021Article
- Multi-faceted enhancement of full-thickness skin wound healing by treatment with autologous micro skin tissue columns.Scientific reports · 2021Article
- Full-thickness Skin Micro-columns within a Dermal Matrix: A Novel Method for "Donor-free" Skin Replacement.Plastic and reconstructive surgery. Global open · 2020Article
- Skin Microcolumns as a Source of Paracrine Signaling Factors.Advances in wound care · 2020Article
- When Wounds Are Good for You: The Regenerative Capacity of Fractional Resurfacing and Potential Utility in Chronic Wound Prevention.Advances in wound care · 2019Review
- Keratinocyte sheets prepared with temperature-responsive dishes show enhanced survival afterRegenerative therapy · 2019Article
- A review of microsampling techniques and their social impact.Biomedical microdevices · 2019Review
- Apparatus for Harvesting Tissue Microcolumns.Journal of visualized experiments : JoVE · 2018Article
- Evaluation of Donor Site Pain After Fractional Autologous Full-Thickness Skin Grafting.Advances in wound care · 2018Article
- Facial Erosive Pustular Dermatosis After Cosmetic Resurfacing.JAMA dermatology · 2017Article
- Reconstitution of full-thickness skin by microcolumn grafting.Journal of tissue engineering and regenerative medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to providing a physical barrier, skin also serves a diverse range of physiological functions through different specialized resident cell types/structures, including melanocytes (pigmentation and protection against ultraviolet radiation), Langerhans cells (adaptive immunity), fibroblasts (maintaining extracellular matrix, paracrine regulation of keratinocytes), sweat glands (thermoregulation) and hair follicles (hair growth, sensation and a stem cell reservoir). Restoration of these functional elements has been a long-standing challenge in efforts to engineer skin tissue, while autologous skin grafting is limited by the scarcity of donor site skin and morbidity caused by skin harvesting. We demonstrate an alternative approach of harvesting and then implanting μm-scale, full-thickness columns of human skin tissue, which can be removed from a donor site with minimal morbidity and no scarring. Fresh human skin microcolumns were used to reconstitute skin in wounds on immunodeficient mice. The restored skin recapitulated many key features of normal human skin tissue, including epidermal architecture, diverse skin cell populations, adnexal structures and sweat production in response to cholinergic stimulation. These promising preclinical results suggest that harvesting and grafting of microcolumns may be useful for reconstituting fully functional skin in human wounds, without donor site morbidity. © 2016 The Authors Journal of Tissue Engineering and Regenerative Medicine Published by John Wiley & Sons Ltd.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.