Evidence map›Paper›PMID 27296171›Full record

ArticleBMC cancer2016

Molecular analyses of unselected head and neck cancer cases demonstrates that human papillomavirus transcriptional activity is positively associated with survival and prognosis.

Liam Masterson, David M Winder, Siolian L R Ball, Katie Vaughan, Martin Lehmann, Lars-Uwe Scholtz, Jane C Sterling, Holger H Sudhoff, Peter K C Goon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Liam MastersonDepartment of Pathology, University of Cambridge, Cambridge, UK.
David M WinderDepartment of Pathology, University of Cambridge, Cambridge, UK.
Siolian L R BallDepartment of Pathology, University of Cambridge, Cambridge, UK.
Katie VaughanDepartment of Pathology, University of Cambridge, Cambridge, UK.
Martin LehmannDepartment of Otorhinolaryngology, Bielefeld Academic Teaching Hospital, Bielefeld, Germany.
Lars-Uwe ScholtzDepartment of Otorhinolaryngology, Bielefeld Academic Teaching Hospital, Bielefeld, Germany.
Jane C SterlingDepartment of Pathology, University of Cambridge, Cambridge, UK.
Holger H SudhoffDepartment of Otorhinolaryngology, Bielefeld Academic Teaching Hospital, Bielefeld, Germany.
Peter K C GoonDepartment of Pathology, University of Cambridge, Cambridge, UK. peter.goon@nhs.net.
University of Cambridge · GBCambridge University Hospitals NHS Foundation Trust · GB

Funding

Cancer Research UK C45051/A14962
6 · The paper itself

Abstract

backgroundHuman papillomavirus DNA detection in head and neck squamous cell carcinoma has been linked to improved patient prognosis. The main aims of the study was to test the hypotheses that HPV16 E6/E7 oncogene and p53 function within tumours were associated with the widely reported improved patient survival and prognosis in head and neck cancer.

methodsHPV16 DNA, mRNA and p53 mRNA presence were analysed in a prospective study of 42 unselected HNSCC patients; correlating the data with patient age, tumour staging/grade, treatment response, disease recurrence and survival.

resultsHPV16 DNA and HPV16 mRNA were present in 45.2 % and 21.4 % of patients, respectively. There was a significant positive association between the detection of HPV16 E6/E7 mRNA and p53 mRNA (p = 0.032), but this was not replicated for HPV16 DNA. Five-year disease free survival for the whole cohort was 63 % (CI 52.5-73.5 %). Multivariable analysis revealed only HPV16 E6/E7 mRNA expression to have significant prognostic influence (p = 0.04).

conclusionsOur study suggests that HPV16 oncogenic transcriptional activity within HNSCC tumours is associated with improved patient survival and better prognosis in a German population. Simple HPV DNA detection alone did not demonstrate this association. The significant association of full-length (wild-type) p53 with HPV16 E6/E7 mRNA is further evidence for a functional relationship, which could contribute to the widely reported improved survival and prognosis. Larger studies are required to validate the frequency of HPV16 mRNA expression in HNSCC.

Indexed as

AgedAged, 80 and overCarcinoma, Squamous CellDisease-Free SurvivalFemaleHead and Neck NeoplasmsHuman papillomavirus 16HumansKaplan-Meier EstimateMaleMiddle AgedMolecular Diagnostic TechniquesNeoplasm Recurrence, LocalOncogene Proteins, ViralPapillomavirus E7 ProteinsPapillomavirus InfectionsE6 protein, Human papillomavirus type 16oncogene protein E7, Human papillomavirus type 16Oncogene Proteins, ViralPapillomavirus E7 ProteinsRepressor ProteinsRNA, MessengerRNA, ViralTP53 protein, humanTumor Suppressor Protein p53HNSCCHuman papillomavirusMolecular diagnosis and prognosisp53

Identifiers

PMID27296171
PMCPMC4906991
OpenAlexW2425840821

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.