ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Preconception Alcohol Increases Offspring Vulnerability to Stress.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior.Neurobiology of stress · 2024Article
- An epigenetic synopsis of parental substance use.Epigenomics · 2023Review
- Maternal epigenetic responsibility: what can we learn from the pandemic?Medicine, health care, and philosophy · 2022Article
- Article
- Preconception Alcohol Exposure Increases the Susceptibility to Diabetes in the Offspring.Endocrinology · 2021Article
- Exposure to drugs of abuse induce effects that persist across generations.International review of neurobiology · 2021Article
- Brain and placental transcriptional responses as a readout of maternal and paternal preconception stress are fetal sex specific.Placenta · 2020Article
- Maternal ethanol consumption before paternal fertilization: Stimulation of hypocretin neurogenesis and ethanol intake in zebrafish offspring.Progress in neuro-psychopharmacology & biological psychiatry · 2020Article
- Intergenerational implications of alcohol intake: metabolic disorders in alcohol-naïve rat offspring.PeerJ · 2020Article
- Intergenerational Effects of Alcohol: A Review of Paternal Preconception Ethanol Exposure Studies and Epigenetic Mechanisms in the Male Germline.Alcoholism, clinical and experimental research · 2019Review
- Pre-conceptional and Peri-Gestational Maternal Binge Alcohol Drinking Produces Inheritance of Mood Disturbances and Alcohol Vulnerability in the Adolescent Offspring.Frontiers in psychiatry · 2018Article
- Alcohol effects on the epigenome in the germline: Role in the inheritance of alcohol-related pathology.Alcohol (Fayetteville, N.Y.) · 2017Review
- Epigenetic mediators and consequences of excessive alcohol consumption.Alcohol (Fayetteville, N.Y.) · 2017Review
- Exploring behavioral phenotypes in a mouse model of fetal alcohol spectrum disorders.Developmental neurobiologyArticle
- Prenatal substance exposure and offspring development: Does DNA methylation play a role?Neurotoxicology and teratologyReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The effect of preconception drinking by the mother on the life-long health outcomes of her children is not known, and therefore, in this study using an animal model, we determined the impact of preconception alcohol drinking of the mother on offspring stress response during adulthood. In our preconception alcohol exposure model, adult female rats were fed with 6.7% alcohol in their diet for 4 weeks, went without alcohol for 3 weeks and were bred to generate male and female offspring. Preconception alcohol-exposed offsprings' birth weight, body growth, stress response, anxiety-like behaviors, and changes in stress regulatory gene and protein hormone levels were evaluated. In addition, roles of epigenetic mechanisms in preconception alcohol effects were determined. Alcohol feeding three weeks prior to conception significantly affected pregnancy outcomes of female rats, with respect to delivery period and birth weight of offspring, without affecting maternal care behaviors. Preconception alcohol negatively affected offspring adult health, producing an increased stress hormone response to an immune challenge. In addition, preconception alcohol was associated with changes in expression and methylation profiles of stress regulatory genes in various brain areas. These changes in stress regulatory genes were normalized following treatment with a DNA methylation blocker during the postnatal period. These data highlight the novel possibility that preconception alcohol affects the inheritance of stress-related diseases possibly by epigenetic mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.