ArticleThe Laryngoscope2017
Molecular analysis of idiopathic subglottic stenosis for Mycobacterium species.
Article in The Laryngoscope, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 62 citations in OpenAlex.
- Impact of Adjuvant Medical Therapies on Surgical Outcomes in Idiopathic Subglottic Stenosis.The Laryngoscope · 2021Trial
- Whole genome sequencing reveals a specific microbiota in subglottic stenosis C. acnes may contribute to inflammation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- An ubiquitous antibacterial toxin from human gut bacteria engenders neonatal colonization advantage.Nature communications · 2026Article
- The evolving clinical profile of laryngeal tuberculosis: a 10-year retrospective study from a tertiary hospital in northern China.BMC infectious diseases · 2026Article
- Northwestern European Ancestry Predominates in Idiopathic Subglottic Stenosis: Results From an English-Speaking Cohort.Laryngoscope investigative otolaryngology · 2026Article
- Cross-kingdom RNA interference in the dysbiosis-mediated network of vocal fold fibrosis: a pathogenic hypothesis and molecular intervention targets.Frontiers in immunology · 2026Review
- Update of Long-Term Outcomes After Cricotracheal Resection for Idiopathic Subglottic Stenosis.The Laryngoscope · 2025Article
- Transcriptomic Features of Recurrence Rates in Idiopathic Subglottic Stenosis.The Laryngoscope · 2025Article
- Metagenomic whole genome shotgun analysis of the airway microbiome in laryngotracheal stenosis: a pilot study.Scientific reports · 2025Article
- Subglottic imaging puncture scope (SIPS) for minimally invasive endoscopy.Scientific reports · 2025Article
- PD-L1 Acts Independently of PD-1 as a Marker of Pathologic Fibroblasts in Laryngotracheal Stenosis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- Review
- Microbiome and Communication Disorders: A Tutorial for Clinicians.Journal of speech, language, and hearing research : JSLHR · 2025Review
- Idiopathic subglottic stenosis in a 32-year-old pregnant woman.European clinical respiratory journal · 2025Article
- Azithromycin Prevents Subglottic Stenosis in Mice.The Laryngoscope · 2025Article
- Similarity Network Analysis of the Adaptive Immune Response in the Proximal Airway.The Laryngoscope · 2024Article
- Reconstructive Surgery of the Laryngotracheal Junction.Laryngo- rhino- otologie · 2024Review
- Dysfunctional Epithelial Barrier Is Characterized by Reduced E-Cadherin in Idiopathic Subglottic Stenosis.The Laryngoscope · 2024Article
- Murine Model of Airway Fibrosis has Anatomic, Physiologic, and Molecular Congruency to Human iSGS.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024Article
- Tracheal microbiome and metabolome profiling in iatrogenic subglottic tracheal stenosis.BMC pulmonary medicine · 2023Article
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 1 country.
Funding
Abstract
objectives/hypothesisIdiopathic subglottic stenosis (iSGS) is an unexplained obstruction involving the lower laryngeal and upper tracheal airway. Persistent mucosal inflammation is a hallmark of the disease. Epithelial microbiota dysbiosis is found in other chronic inflammatory mucosal diseases; however, the relationship between tracheal microbiota composition and iSGS is unknown. Given the critical role for host defense at mucosal barriers, we analyzed tissue specimens from iSGS patients for the presence of microbial pathogens.
methodsUtilizing 30 human iSGS, 20 intubation-related tracheal stenosis (iLTS), and 20 healthy control specimens, we applied molecular, immunohistochemical, electron microscopic, immunologic, and Sanger-sequencing techniques.
resultsWith unbiased culture-independent nucleic acid, protein, and immunologic approaches, we demonstrate that Mycobacterium species are uniquely associated with iSGS. Phylogenetic analysis of the mycobacterial virulence factor rpoB suggests that, rather than Mycobacterium tuberculosis, a variant member of the Mycobacterium tuberculosis complex or a closely related novel mycobacterium is present in iSGS specimens.
conclusionThese studies identify a novel pathogenic role for established large airway bacteria and provide new targets for future therapeutic intervention. LEVEL OF EVIDENCE: NA Laryngoscope, 127:179-185, 2017.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.