ArticleJournal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society2016
Cobalt-Chromium Metallosis With Normal Electroretinogram.
Article in Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Cobalt-induced Retinopathy: Unveiling the hidden risk of knee prosthesis.American journal of ophthalmology case reports · 2025Article
- In Vivo Imaging of Cobalt-Induced Ocular Toxicity in a Mouse Model.Methods and protocols · 2025Article
- Cobalt Toxicity Presenting as Bilateral Optic Neuropathy.Ochsner journal · 2025Article
- Cobalt Toxicity Induces Retinopathy and Optic Neuropathy in Mice.Investigative ophthalmology & visual science · 2024Article
- An Update Overview on Mechanistic Data and Biomarker Levels in Cobalt and Chromium-Induced Neurodegenerative Diseases.Biological trace element research · 2024Review
- Prosthetic hip-associated cobalt toxicity: a systematic review of case series and case reports.EFORT open reviews · 2022Review
- Clinical electrophysiology of the optic nerve and retinal ganglion cells.Eye (London, England) · 2021Review
- Cobalt toxic optic neuropathy and retinopathy: Case report and review of the literature.American journal of ophthalmology case reports · 2020Article
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5 authors.
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Abstract
backgroundOcular cobalt toxicity is a rare phenomenon reported with increased frequency due to the rise of cobalt-chromium metal hip implants. We report the case of a 66-year-old previously healthy man who developed decreased vision due to cobalt-chromium toxicity from a metal-on-metal hip arthroplasty. Our objective was to determine whether the origin of his visual loss was due to toxicity of the optic nerve, of the retina, or of both.
methodsOcular examination, 10-2 SITA-Standard Humphrey Visual Field (VF), standard full-field electroretinogram (ERG) as indicated by the International Society for Clinical Electrophysiology of Vision (ISCEV), multifocal electroretinogram (mfERG), multifocal visual evoked potentials (mfVEP), and optical coherence tomography (OCT) were conducted.
resultsOcular examination revealed decreased visual acuity, poor color vision, normal funduscopy, and cecocentral scotomas on VF testing. Because his right eye was amblyopic since childhood, test results from only the left eye are shown. Electrophysiology studies revealed an ISCEV standard full-field ERG with photopic and scotopic responses within normal limits, mfERG with amplitudes and latencies within normal limits, and mfVEP with latencies within normal limits, but with decreased central amplitudes. Peripapillary and macular OCT showed retinal nerve fiber layer and retinal ganglion cell-inner plexiform layer thickness within normal limits.
conclusionBecause decreased color vision and cecocentral scotoma on 10-2 VF are most consistent with toxic optic neuropathy, and decreased central amplitudes on mfVEP are suggestive of neural dysfunction, we hypothesize that our patient presented with an early stage of optic nerve toxicity that was not yet apparent as a structural abnormality on OCT.
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