ArticlePLoS computational biology2016
Large Scale Chromosome Folding Is Stable against Local Changes in Chromatin Structure.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Article
- Predicting scale-dependent chromatin polymer properties from systematic coarse-graining.Nature communications · 2023Article
- Mesoscale, long-time mixing of chromosomes and its connection to polymer dynamics.PLoS computational biology · 2023Article
- Advances and challenges in CRISPR-based real-time imaging of dynamic genome organization.Frontiers in molecular biosciences · 2023Review
- Loops, topologically associating domains, compartments, and territories are elastic and robust to dramatic nuclear volume swelling.Scientific reports · 2022Article
- The Physical Behavior of Interphase Chromosomes: Polymer Theory and Coarse-Grain Computer Simulations.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Monitoring the spatio-temporal organization and dynamics of the genome.Nucleic acids research · 2020Review
- Disordered chromatin packing regulates phenotypic plasticity.Science advances · 2020Article
- Polymer Simulations of Heteromorphic Chromatin Predict the 3D Folding of Complex Genomic Loci.Molecular cell · 2018Article
- Reorganization ofThe EMBO journal · 2018Article
- How epigenome drives chromatin folding and dynamics, insights from efficient coarse-grained models of chromosomes.PLoS computational biology · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Characterizing the link between small-scale chromatin structure and large-scale chromosome folding during interphase is a prerequisite for understanding transcription. Yet, this link remains poorly investigated. Here, we introduce a simple biophysical model where interphase chromosomes are described in terms of the folding of chromatin sequences composed of alternating blocks of fibers with different thicknesses and flexibilities, and we use it to study the influence of sequence disorder on chromosome behaviors in space and time. By employing extensive computer simulations, we thus demonstrate that chromosomes undergo noticeable conformational changes only on length-scales smaller than 105 basepairs and time-scales shorter than a few seconds, and we suggest there might exist effective upper bounds to the detection of chromosome reorganization in eukaryotes. We prove the relevance of our framework by modeling recent experimental FISH data on murine chromosomes.
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Registered trials
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