ArticleJournal of the American Geriatrics Society2016
Mortality in Individuals Aged 80 and Older with Type 2 Diabetes Mellitus in Relation to Glycosylated Hemoglobin, Blood Pressure, and Total Cholesterol.
Article in Journal of the American Geriatrics Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Glycemic control and clinical outcomes in patients with diabetes and atrial fibrillation: a nationwide cohort study.Acta diabetologica · 2026Article
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- Review on the management of cardiovascular risk factors in the elderly.Journal of geriatric cardiology : JGC · 2022Article
- Association of Diabetes Duration and Glycemic Control With Stroke Rate in Patients With Atrial Fibrillation and Diabetes: A Population-Based Cohort Study.Journal of the American Heart Association · 2022Article
- Glycaemic markers and all-cause mortality in older adults with and without diabetes: the Atherosclerosis Risk in Communities (ARIC) study.Diabetologia · 2021Article
- Statin Treatment in Specific Patient Groups: Role for Improved Cardiovascular Risk Markers.Journal of clinical medicine · 2020Review
- Current situation analysis of diabetic home care patients.Northern clinics of Istanbul · 2020Article
- Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes.Scientific reports · 2019Article
- Verification of Kumamoto Declaration 2013 and Glycemic Targets for Elderly Patients with Diabetes in Japan for prevention of diabetic complications: A retrospective longitudinal study using outpatient clinical data.Journal of diabetes investigation · 2019Article
- Diabetes in the older patient: heterogeneity requires individualisation of therapeutic strategies.Diabetologia · 2018Review
- Low glycated hemoglobin level is associated with severity of frailty in Japanese elderly diabetes patients.Journal of diabetes investigation · 2018Article
- Deprescribing in Older Nursing Home Patients: Focus on Innovative Composite Measures for Dosage Deintensification.Innovation in aging · 2017Review
- Declining blood pressure and intensification of blood pressure management among people over 80 years: cohort study using electronic health records.Journal of hypertension · 2017Article
- Evolution of the "fourth stage" of epidemiologic transition in people aged 80 years and over: population-based cohort study using electronic health records.Population health metrics · 2017Article
- Drug prescribing during the last year of life in very old people with diabetes.Age and ageing · 2017Article
- Mortality in Individuals Aged 80 and Older with Type 2 Diabetes Mellitus in Relation to Glycosylated Hemoglobin, Blood Pressure, and Total Cholesterol.Journal of the American Geriatrics Society · 2016Article
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2 authors.
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Abstract
objectivesTo evaluate whether low glycosylated hemoglobin (HbA1c), blood pressure (BP), and total cholesterol (TC) are associated with lower risk of all-cause mortality in very old individuals with type 2 diabetes mellitus.
designPopulation-based cohort study.
settingPrimary care database in the United Kingdom.
participantsIndividuals aged 80 and older with type 2 diabetes mellitus (N = 25,966). MEASUREMENTS: Associations between baseline HbA1c, BP, and TC and all-cause mortality were evaluated in Cox proportional hazards models. Analyses were adjusted for sex, age, duration of diabetes mellitus, lifestyle variables, HbA1c, BP, TC, comorbidities, prescribing of antidiabetic and cardiovascular drugs, and participants' general practice.
resultsThere were 4,490 deaths during follow-up (median 2.0 years; mortality 104.7 per 1,000 person-years). Mortality in participants with low (<6.0% (<42 mmol/mol)) or high (≥8.5% (≥69 mmol/mol)) HbA1c was similar to that in those with the reference HbA1c (8.0-8.4% (64-68 mmol/mol)). Mortality was lowest in individuals with HbA1c of 7.0-7.4% (53-57 mmol/mol) (80.9 per 1,000 person-years, adjusted hazard ratio (aHR) = 0.80, 95% confidence interval (CI) = 0.70-0.91, P = .001). Mortality was higher in individuals with lower BP (e.g., <130/70 mmHg, 151.7 per 1,000 person-years, aHR = 1.52, 95% CI = 1.34-1.72, P < .001 vs reference BP <150/90 mmHg) and in the lowest TC category (<3.0 mmol/L, 138.7 per 1,000 person-years, aHR = 1.42, 95% CI = 1.24-1.64, P < .001 vs reference TC 4.5-4.9 mmol/L). The relationship between TC and mortality varied according to sex and prescription of lipid-lowering drugs.
conclusionLow HbA1c, BP, and TC may be associated with higher mortality in very old adults with type 2 diabetes mellitus. Further research is required to understand these associations and to identify optimal treatment targets in this population.
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