Evidence map›Paper›PMID 27295210›Full record

SynthesisPloS one2016

Fecal Microbiota Transplantation for Ulcerative Colitis: A Systematic Review and Meta-Analysis.

Yanqiang Shi, Yiwei Dong, Wenhui Huang, Decong Zhu, Hua Mao, Peizhu Su

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03194529 (Safety of FMT in Maintenance of Pediatric Crohn's Disease), which is not on this map. Cited by 61 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 7 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03194529 phase1 / phase2completednot on this mapstarted 2017, after this paper: background citation

Safety of FMT in Maintenance of Pediatric Crohn's Disease

TypeinterventionalSponsorChildren's Hospital Los AngelesRan2017 to 2019Enrolled9ConditionsCrohn Disease, Pediatric Crohns DiseaseArmsFMT
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 7 syntheses or guidelines pooled it, 114 citations in OpenAlex.

  1. Pooled it
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  6. Fecal transplantation for treatment of inflammatory bowel disease.The Cochrane database of systematic reviews · 2018
    Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. High-throughput analyses ofGut microbes · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Biomarkers Unveiling the Interplay of Mind, Nervous System, and Immunity.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yanqiang ShiThe Second Clinical Medical School, Southern Medical University, 510280, Guangzhou City, Guangdong Province, China.
Yiwei DongThe Second Clinical Medical School, Southern Medical University, 510280, Guangzhou City, Guangdong Province, China.
Wenhui HuangThe Second Clinical Medical School, Southern Medical University, 510280, Guangzhou City, Guangdong Province, China.
Decong ZhuThe Second Clinical Medical School, Southern Medical University, 510280, Guangzhou City, Guangdong Province, China.
Hua MaoDepartment of Gastroenterology, Zhujiang Hospital, Southern Medical University, 510280, Guangzhou City, Guangdong Province, China.
Peizhu SuDepartment of Gastroenterology, Zhujiang Hospital, Southern Medical University, 510280, Guangzhou City, Guangdong Province, China.
Southern Medical University · CNZhujiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFecal microbiota transplantation (FMT) has been recognized as a novel treatment for ulcerative colitis (UC). However, its efficacy and safety remain unclear.

objectiveWe conducted this systematic review to assess the efficacy and safety of FMT in UC. DATA SOURCES: PubMed, EMBASE, Cochrane Central, Web of Science Core Collection, and three other Chinese databases were searched for reports of FMT in UC with clear outcomes. DATA EXTRACTION AND SYNTHESIS: We estimated pooled rates [with 95% confidence interval (CI)] of clinical remission among 15 cohort studies and clinical response among 16 cohort studies.

resultsTwenty five studies (2 randomized controlled trials, 15 cohort studies, and 8 case studies) with 234 UC patients were included. Overall, 41.58% (84/202) patients achieved clinical remission (CR) and 65.28% (126/193) achieved clinical response. Among the cohort studies, the pooled estimate of patients who achieved CR and clinical response were 40.5% (95% CI 24.7%-58.7%), and 66.1% (95% CI 43.7%-83.0%). Most adverse events were slight and self-resolving. The analyses of gut microbiota in 7 studies showed that FMT could increase microbiota diversity and richness, similarity, and certain change of bacterial composition.

conclusionFMT provides a promising effect for UC with few adverse events. Successful FMT may be associated with an increase in microbiota diversity and richness, similarity, and certain change of bacterial composition.

Indexed as

Gastrointestinal MicrobiomeColitis, UlcerativeFecal Microbiota TransplantationFecesHumansRemission InductionTreatment Outcome

Identifiers

PMID27295210
PMCPMC4905678
OpenAlexW2425423977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.