ArticleStress (Amsterdam, Netherlands)2016
CD4(+) T cells confer anxiolytic and antidepressant-like effects, but enhance fear memory processes in Rag2(-/-) mice.
Article in Stress (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Immunity in Rodent Models of Stress.Biological psychiatry · 2026Review
- Article
- Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression.Brain, behavior, & immunity - health · 2025Article
- Integrated Single-Cell RNA-seq and ATAC-seq Reveals Heterogeneous Differentiation of CD4Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Social stress induces autoimmune responses against the brain.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Stress promotes the infiltration of peripheral immune cells to the brain.Brain, behavior, and immunity · 2023Article
- The NLRP3 Inflammasome in Stress Response: Another Target for the Promiscuous Cannabidiol.Current neuropharmacology · 2023Review
- Lymphocyte deficiency alters the transcriptomes of oligodendrocytes, but not astrocytes or microglia.PloS one · 2023Article
- Mouse models of immune dysfunction: their neuroanatomical differences reflect their anxiety-behavioural phenotype.Molecular psychiatry · 2022Article
- Targeting the Adaptive Immune System in Depression: Focus on T Helper 17 Cells.Pharmacological reviews · 2022Review
- Estrogen, the Peripheral Immune System and Major Depression - A Reproductive Lifespan Perspective.Frontiers in behavioral neuroscience · 2022Review
- Neuroimmune mechanisms in fear and panic pathophysiology.Frontiers in psychiatry · 2022Review
- Inflamed brain: Targeting immune changes and inflammation for treatment of depression.Psychiatry and clinical neurosciences · 2021Review
- Treatment with a heat-killed preparation of Mycobacterium vaccae after fear conditioning enhances fear extinction in the fear-potentiated startle paradigm.Brain, behavior, and immunity · 2019Article
- CD8Cytokine · 2019Article
- T Cells as an Emerging Target for Chronic Pain Therapy.Frontiers in molecular neuroscience · 2019Article
- Increased circulating regulatory T cells in medicated people with schizophrenia.Psychiatry research · 2018Article
- Distinct characteristics of hippocampal pathogenic TBrain, behavior, and immunity · 2018Article
- A peripheral immune response to remembering trauma contributes to the maintenance of fear memory in mice.Psychoneuroendocrinology · 2018Article
- Neonatal adoptive transfer of lymphocytes rescues social behaviour during adolescence in immune-deficient mice.The European journal of neuroscience · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Accumulating evidence supports a role of T cells in behavioral stress responsiveness. Our laboratory previously reported that lymphocyte deficient Rag2(-/-) mice on a BALB/c background display resilience to maladaptive stress responses when compared with immune competent mice in the predator odor exposure (POE) paradigm, while exhibiting similar behavior in a cued fear-conditioning (FC) paradigm. In the present study, Rag2(-/-) mice on a C57BL/6 background were assessed in the same behavioral paradigms, as well as additional tests of anxiety and depressive-like behavior. Furthermore, the effects of naïve CD4(+ ) T cells were evaluated by adoptive transfer of functional cells from nonstressed, wild-type donors to Rag2(-/-) mice. Consistent with our prior results, Rag2(-/-) mice displayed an attenuated startle response after POE. Nevertheless, reconstitution of Rag2(-/-) mice with CD4(+ ) T cells did not modify startle reactivity. Additionally, in contrast with our previous findings, Rag2(-/-) mice showed attenuated fear responses in the FC paradigm compared to wild-type mice and reconstitution with CD4(+ ) T cells promoted fear learning and memory. Notably, reconstitution with CD4(+ ) T cells had anxiolytic and antidepressant-like effects in Rag2(-/-) mice that had not been previously stressed, but had no effect after POE. Taken together, our results support a role of CD4(+ ) T cells in emotionality, but also indicate that they may promote fear responses by enhancing learning and memory processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.