Evidence map›Paper›PMID 27295037›Full record

ArticlePloS one2016

microRNA-153 Targets mTORC2 Component Rictor to Inhibit Glioma Cells.

Yan Cui, Jizong Zhao, Lei Yi, Yugang Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

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  14. [MicroRNA-152 and microRNA-448 inhibit proliferation of colorectal cancer cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Yan CuiDepartment of Neurosurgery, the Second Xiangya Hospital of Central South University, Chang Sha, 410011,China.
Jizong ZhaoDepartment of Neurosurgery, the Second Xiangya Hospital of Central South University, Chang Sha, 410011,China.
Lei YiDepartment of Neurosurgery, the Second Xiangya Hospital of Central South University, Chang Sha, 410011,China.
Yugang JiangDepartment of Neurosurgery, the Second Xiangya Hospital of Central South University, Chang Sha, 410011,China.
Central South University · CNBeijing Tian Tan Hospital · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rictor upregulation and mTORC complex 2 (mTORC2) over-activation participate in glioma cell progression, yet the underling mechanisms are not known. We here identified microRNA-153 (miR-153) as a potential anti-Rictor miRNA, which was downregulated in multiple human glioma tissues and glioma cell lines (U87MG, T98G, U373MG and U251MG). miR-153 downregulation was correlated with Rictor (mRNA and protein) upregulation and p-Akt Ser473 (the mTORC2 indicator) over-activation in the glioma tissues and cells. Our in vitro evidences suggested that Rictor could be one primary target of miR-153 in glioma cells. Exogenous overexpression of miR-153 downregulated Rictor (mRNA and protein) and decreased p-Akt Ser473 in U87MG cells, leading to significant growth inhibition and apoptosis activation. Notably, U87MG cells with Rictor shRNA knockdown showed similar phenotypes of cells with miR-153 overexpression. More importantly, in Rictor-silenced U87MG cells, miR-153 expression failed to further affect cell growth nor apoptosis. In vivo, we showed that miR-153 overexpression dramatically inhibited U87MG tumor growth in nude mice. Together, these results suggest that miR-153 downregulation could be one important reason of Rictor upregulation and mTORC2 over-activation in glioma cells. Further, miR-153-induced anti-glioma cell activity is possibly via downregulating Rictor.

Indexed as

AnimalsCarrier ProteinsCell Line, TumorCell ProliferationDown-RegulationFemaleGene Expression Regulation, NeoplasticGliomaHumansMechanistic Target of Rapamycin Complex 2MiceMice, NudeMicroRNAsMultiprotein ComplexesRapamycin-Insensitive Companion of mTOR ProteinTOR Serine-Threonine KinasesCarrier ProteinsMechanistic Target of Rapamycin Complex 2MicroRNAsMIRN153 microRNA, humanMultiprotein ComplexesRapamycin-Insensitive Companion of mTOR ProteinRICTOR protein, humanTOR Serine-Threonine Kinases

Identifiers

PMID27295037
PMCPMC4905671
OpenAlexW2442188841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.